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BDBM50043355 10-[2-(4-Benzyloxy-phenyl)-acetyl]-1,8-dihydroxy-10H-anthracen-9-one::CHEMBL130038

SMILES: Oc1cccc2C(C(=O)Cc3ccc(OCc4ccccc4)cc3)c3cccc(O)c3C(=O)c12

InChI Key: InChIKey=YIVXRIKQEZBYQB-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50043355   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043355
PNG
(10-[2-(4-Benzyloxy-phenyl)-acetyl]-1,8-dihydroxy-1...)
Show SMILES Oc1cccc2C(C(=O)Cc3ccc(OCc4ccccc4)cc3)c3cccc(O)c3C(=O)c12
Show InChI InChI=1S/C29H22O5/c30-23-10-4-8-21-26(22-9-5-11-24(31)28(22)29(33)27(21)23)25(32)16-18-12-14-20(15-13-18)34-17-19-6-2-1-3-7-19/h1-15,26,30-31H,16-17H2
PDB
MMDB

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n/an/a 600n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)


BindingDB Entry DOI: 10.7270/Q2G44PC2
More data for this
Ligand-Target Pair