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BDBM50043358 (E)-1,8-Dihydroxy-10-[3-(3-methoxy-phenyl)-acryloyl]-10H-anthracen-9-one::CHEMBL433846

SMILES: COc1cccc(C=CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)c1

InChI Key: InChIKey=BCLNDDOCALUAHU-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50043358   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043358
PNG
((E)-1,8-Dihydroxy-10-[3-(3-methoxy-phenyl)-acryloy...)
Show SMILES COc1cccc(C=CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)c1 |w:7.6|
Show InChI InChI=1S/C24H18O5/c1-29-15-6-2-5-14(13-15)11-12-20(27)21-16-7-3-9-18(25)22(16)24(28)23-17(21)8-4-10-19(23)26/h2-13,21,25-26H,1H3
PDB
MMDB

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UniProtKB/TrEMBL

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)


BindingDB Entry DOI: 10.7270/Q2G44PC2
More data for this
Ligand-Target Pair