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BDBM50043359 1,8-Dihydroxy-10-[2-(4-hydroxy-phenyl)-acetyl]-10H-anthracen-9-one::CHEMBL133058

SMILES: Oc1ccc(CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1

InChI Key: InChIKey=QKVUGRSIFXNRPS-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50043359   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043359
PNG
(1,8-Dihydroxy-10-[2-(4-hydroxy-phenyl)-acetyl]-10H...)
Show SMILES Oc1ccc(CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1
Show InChI InChI=1S/C22H16O5/c23-13-9-7-12(8-10-13)11-18(26)19-14-3-1-5-16(24)20(14)22(27)21-15(19)4-2-6-17(21)25/h1-10,19,23-25H,11H2
PDB
MMDB

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UniProtKB/TrEMBL

B.MOAD
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CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes


J Med Chem 36: 4099-107 (1994)


BindingDB Entry DOI: 10.7270/Q2G44PC2
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Bos taurus)
BDBM50043359
PNG
(1,8-Dihydroxy-10-[2-(4-hydroxy-phenyl)-acetyl]-10H...)
Show SMILES Oc1ccc(CC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1
Show InChI InChI=1S/C22H16O5/c23-13-9-7-12(8-10-13)11-18(26)19-14-3-1-5-16(24)20(14)22(27)21-15(19)4-2-6-17(21)25/h1-10,19,23-25H,11H2
PDB
MMDB

Reactome pathway

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).


J Med Chem 36: 4099-107 (1994)


BindingDB Entry DOI: 10.7270/Q2G44PC2
More data for this
Ligand-Target Pair