BDBM50043450 3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-4-ylmethyl)-indole-1-carbonyl]-benzoic acid::CHEMBL337086

SMILES: CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O

InChI Key: InChIKey=WYDDCASXOCGRQH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50043450   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiotensin II type 1a (AT-1a) receptor (RABBIT)	BDBM50043450 (3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...) Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O Show InChI InChI=1S/C27H22Cl2N4O3/c1-4-21-31-24-14(2)11-15(3)30-25(24)33(21)13-16-5-8-20-17(12-16)9-10-32(20)26(34)22-18(28)6-7-19(29)23(22)27(35)36/h5-12H,4,13H2,1-3H3,(H,35,36)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.				J Med Chem 36: 4230-8 (1994) BindingDB Entry DOI: 10.7270/Q26M35X0
					More data for this Ligand-Target Pair
Angiotensin II type 1a (AT-1a) receptor (RABBIT)	BDBM50043450 (3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...) Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O Show InChI InChI=1S/C27H22Cl2N4O3/c1-4-21-31-24-14(2)11-15(3)30-25(24)33(21)13-16-5-8-20-17(12-16)9-10-32(20)26(34)22-18(28)6-7-19(29)23(22)27(35)36/h5-12H,4,13H2,1-3H3,(H,35,36)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
The M. S. University of Baroda Curated by ChEMBL					Assay Description Binding affinity to angiotensin AT1 receptor in rabbit aortic rings				Bioorg Med Chem 18: 8418-56 (2010) Article DOI: 10.1016/j.bmc.2010.10.043 BindingDB Entry DOI: 10.7270/Q2H70G3T
					More data for this Ligand-Target Pair
Angiotensin II AT2 (RAT)	BDBM50043450 (3,6-Dichloro-2-[5-(2-ethyl-5,7-dimethyl-3H-imidazo...) Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc2n(ccc2c1)C(=O)c1c(Cl)ccc(Cl)c1C(O)=O Show InChI InChI=1S/C27H22Cl2N4O3/c1-4-21-31-24-14(2)11-15(3)30-25(24)33(21)13-16-5-8-20-17(12-16)9-10-32(20)26(34)22-18(28)6-7-19(29)23(22)27(35)36/h5-12H,4,13H2,1-3H3,(H,35,36)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.				J Med Chem 36: 4230-8 (1994) BindingDB Entry DOI: 10.7270/Q26M35X0
					More data for this Ligand-Target Pair