BDBM50043906 CHEMBL269001::Dorzolamide::MK-507::US10172837, Dorzolamide
SMILES: CCNC1CC(C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O
InChI Key: InChIKey=IAVUPMFITXYVAF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
6-phosphogluconate dehydrogenase (6PGD) (Homo sapiens (Human)) | BDBM50043906 (CHEMBL269001 | Dorzolamide | MK-507 | US10172837, ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 3.14E+6 | n/a | 1.41E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Dumlupinar University | Assay Description The enzyme activities in the absence of drugs or chemicals were taken as 100%. For each drug or chemical, an activity%-(drug) graph was drawn and dr... | J Enzyme Inhib Med Chem 23: 418-23 (2008) Article DOI: 10.1080/14756360701546413 BindingDB Entry DOI: 10.7270/Q2F18XBP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Carbonic anhydrase 1 (Homo sapiens (Human)) | BDBM50043906 (CHEMBL269001 | Dorzolamide | MK-507 | US10172837, ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Naia Metabolic, Inc. US Patent | Assay Description Compounds which are CAIs are well known in the art, see for example, Pastorekova et al, Journal of Enzyme Inhibition and Medicinal Chemistry, 19(3), ... | US Patent US10172837 (2019) BindingDB Entry DOI: 10.7270/Q2VT1V5M | |||||||||||
More data for this Ligand-Target Pair |