BDBM50043916 CHEMBL3356041::US9174993, 64

SMILES: Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2ccccc2Cl)cc1

InChI Key: InChIKey=WGVJUOAKNOUUNO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50043916   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50043916 (CHEMBL3356041 | US9174993, 64) Show SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2ccccc2Cl)cc1 Show InChI InChI=1S/C17H13ClN6O2S/c18-12-3-1-2-4-14(12)27(25,26)24-11-7-5-10(6-8-11)13-9-20-15-16(19)22-23-17(15)21-13/h1-9,24H,(H3,19,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
SANOFI US Patent					Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...				US Patent US9174993 (2015) BindingDB Entry DOI: 10.7270/Q2MK6BPF
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50043916 (CHEMBL3356041 | US9174993, 64) Show SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2ccccc2Cl)cc1 Show InChI InChI=1S/C17H13ClN6O2S/c18-12-3-1-2-4-14(12)27(25,26)24-11-7-5-10(6-8-11)13-9-20-15-16(19)22-23-17(15)21-13/h1-9,24H,(H3,19,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R&D Curated by ChEMBL					Assay Description Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50043916 (CHEMBL3356041 | US9174993, 64) Show SMILES Nc1n[nH]c2nc(cnc12)-c1ccc(NS(=O)(=O)c2ccccc2Cl)cc1 Show InChI InChI=1S/C17H13ClN6O2S/c18-12-3-1-2-4-14(12)27(25,26)24-11-7-5-10(6-8-11)13-9-20-15-16(19)22-23-17(15)21-13/h1-9,24H,(H3,19,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi R&D Curated by ChEMBL					Assay Description Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence...				ACS Med Chem Lett 6: 73-8 (2015) Article DOI: 10.1021/ml5003376 BindingDB Entry DOI: 10.7270/Q28S4RJT
					More data for this Ligand-Target Pair