BDBM50044008 CHEMBL3356428

SMILES: CN(C)C(=O)Oc1cccc(NC(=O)C2(O)CCN(CC2)c2ncnc3[nH]cc(C)c23)c1

InChI Key: InChIKey=JFKVNPYSINXUEZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50044008   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
LIM domain kinase 2 (Homo sapiens (Human))	BDBM50044008 (CHEMBL3356428) Show SMILES CN(C)C(=O)Oc1cccc(NC(=O)C2(O)CCN(CC2)c2ncnc3[nH]cc(C)c23)c1 Show InChI InChI=1S/C22H26N6O4/c1-14-12-23-18-17(14)19(25-13-24-18)28-9-7-22(31,8-10-28)20(29)26-15-5-4-6-16(11-15)32-21(30)27(2)3/h4-6,11-13,31H,7-10H2,1-3H3,(H,26,29)(H,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
Lexicon Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human full-length LIMK2 assessed as incorporation of P33 from ATP into biotinylated-cofilin substrate by scintillation counting analysi...				ACS Med Chem Lett 6: 84-8 (2015) Article DOI: 10.1021/ml500367g BindingDB Entry DOI: 10.7270/Q218384X
					More data for this Ligand-Target Pair