Found 19 hits for monomerid = 50044140 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
UniProtKB/SwissProt
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| PubMed
| 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 233: 597-602 (1985)
BindingDB Entry DOI: 10.7270/Q20R9MWQ |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
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| PDB Article PubMed
| 1.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Sigma non-opioid intracellular receptor 1
(RAT) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
UniProtKB/SwissProt
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| 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 233: 597-602 (1985)
BindingDB Entry DOI: 10.7270/Q20R9MWQ |
More data for this Ligand-Target Pair | |
NMDA receptor subtype 2A protein (NR2A)
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
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| PDB Article PubMed
| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Auckland
Curated by ChEMBL
| Assay Description Binding affinity to NMDA receptor (unknown origin) |
Bioorg Med Chem 27: 1226-1231 (2019)
Article DOI: 10.1016/j.bmc.2019.02.010 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
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| 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merz Co. GmbH & Co.
Curated by PDSP Ki Database
| |
Neuropharmacology 34: 533-40 (1995)
Article DOI: 10.1016/0028-3908(95)00017-z BindingDB Entry DOI: 10.7270/Q2M9075F |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Butyrylcholinesterase (BuChE)
(Equus caballus (Horse)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
| Assay Description Inhibition of equine serum BChE by modified Ellman's method |
J Med Chem 53: 3611-7 (2010)
Article DOI: 10.1021/jm1000024 BindingDB Entry DOI: 10.7270/Q2SJ1KS0 |
More data for this Ligand-Target Pair | |
Bile salt export pump (BSEP)
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
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| Article PubMed
| n/a | n/a | >1.35E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t... |
Toxicol Sci 118: 485-500 (2010)
Article DOI: 10.1093/toxsci/kfq269 BindingDB Entry DOI: 10.7270/Q26Q20JN |
More data for this Ligand-Target Pair | |
Multidrug resistance-associated protein 4
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Canalicular multispecific organic anion transporter 1
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | UniProtKB/SwissProt
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| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Canalicular multispecific organic anion transporter 2
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| PubMed
| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
UniProtKB/SwissProt
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| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ... |
Toxicol Sci 136: 216-41 (2013)
BindingDB Entry DOI: 10.7270/Q2JM2D2D |
More data for this Ligand-Target Pair | |
NR1/NR2A
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| PDB Article PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 21: 2059-63 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.009 BindingDB Entry DOI: 10.7270/Q26W9DXX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
GluN1/GluN2B NMDA receptor
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| PDB Article PubMed
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Medicines Research Centre
Curated by ChEMBL
| Assay Description Inhibition of human recombinant NR1/NR2B receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assay |
Bioorg Med Chem Lett 21: 2059-63 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.009 BindingDB Entry DOI: 10.7270/Q26W9DXX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
NR1/NR2A
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Similars
| PDB Article PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
| Assay Description Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assess... |
J Med Chem 53: 3611-7 (2010)
Article DOI: 10.1021/jm1000024 BindingDB Entry DOI: 10.7270/Q2SJ1KS0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
GluN1/GluN2B NMDA receptor
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Similars
| PDB Article PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
| Assay Description Inhibition of dexamethasone-induced human NR1-1a/NR2B receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L13-E6 cells assesse... |
J Med Chem 53: 3611-7 (2010)
Article DOI: 10.1021/jm1000024 BindingDB Entry DOI: 10.7270/Q2SJ1KS0 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 2.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of sodium channels through phasic blockade |
J Med Chem 46: 2494-501 (2003)
Article DOI: 10.1021/jm020546r BindingDB Entry DOI: 10.7270/Q2MW2GHF |
More data for this Ligand-Target Pair | |
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 8.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by ChEMBL
| Assay Description Inhibition of sodium channels through tonic blockade |
J Med Chem 46: 2494-501 (2003)
Article DOI: 10.1021/jm020546r BindingDB Entry DOI: 10.7270/Q2MW2GHF |
More data for this Ligand-Target Pair | |
NR1/NR2A
(Homo sapiens (Human)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| PDB Article PubMed
| n/a | n/a | 3.31E+3 | n/a | n/a | n/a | n/a | 7.6 | n/a |
Xavier University of Louisiana
Curated by ChEMBL
| Assay Description Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced cur... |
Bioorg Med Chem 22: 1983-92 (2014)
Article DOI: 10.1016/j.bmc.2014.02.049 BindingDB Entry DOI: 10.7270/Q2N29ZGG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholinesterase
(Electrophorus electricus (Electric eel)) | BDBM50044140
(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)Show InChI InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3 | UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Friedrich-Schiller-Universitat Jena
Curated by ChEMBL
| Assay Description Inhibition of electric eel AChE by modified Ellman's method |
J Med Chem 53: 3611-7 (2010)
Article DOI: 10.1021/jm1000024 BindingDB Entry DOI: 10.7270/Q2SJ1KS0 |
More data for this Ligand-Target Pair | |