BDBM50044302 CHEMBL3357438

SMILES: CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)NC(C)(C)C)c2)ncc1Cl

InChI Key: InChIKey=YUMFNFPTDIQTLX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50044302   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50044302 (CHEMBL3357438) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)NC(C)(C)C)c2)ncc1Cl Show InChI InChI=1S/C25H28ClFN8O3/c1-25(2,3)35-24(38)30-13-19(36)31-14-7-5-8-15(11-14)32-23-29-12-17(26)21(34-23)33-20-16(22(37)28-4)9-6-10-18(20)27/h5-12H,13H2,1-4H3,(H,28,37)(H,31,36)(H2,30,35,38)(H2,29,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of ALK (unknown origin) after 60 mins by ELISA				J Med Chem 58: 197-211 (2015) Article DOI: 10.1021/jm5005144 BindingDB Entry DOI: 10.7270/Q2FB54MQ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50044302 (CHEMBL3357438) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2cccc(NC(=O)CNC(=O)NC(C)(C)C)c2)ncc1Cl Show InChI InChI=1S/C25H28ClFN8O3/c1-25(2,3)35-24(38)30-13-19(36)31-14-7-5-8-15(11-14)32-23-29-12-17(26)21(34-23)33-20-16(22(37)28-4)9-6-10-18(20)27/h5-12H,13H2,1-4H3,(H,28,37)(H,31,36)(H2,30,35,38)(H2,29,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of c-Met kinase (unknown origin) after 60 mins by ELISA				J Med Chem 58: 197-211 (2015) Article DOI: 10.1021/jm5005144 BindingDB Entry DOI: 10.7270/Q2FB54MQ
					More data for this Ligand-Target Pair