BDBM50044454 8-(3-Phenoxy-propyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL314702

SMILES: O=C1NCN(c2ccccc2)C11CCN(CCCOc2ccccc2)CC1

InChI Key: InChIKey=ZMPJCXQJCGGYPL-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50044454   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serotonin 2 (5-HT2) receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)	BDBM50044454 (8-(3-Phenoxy-propyl)-1-phenyl-1,3,8-triaza-spiro[4...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CCCOc2ccccc2)CC1 Show InChI InChI=1S/C22H27N3O2/c26-21-22(25(18-23-21)19-8-3-1-4-9-19)12-15-24(16-13-22)14-7-17-27-20-10-5-2-6-11-20/h1-6,8-11H,7,12-18H2,(H,23,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Tested for binding affinity against 5-hydroxytryptamine 2 receptor from rat frontal cortical regions using [3H]ketanserin as radioligand				J Med Chem 36: 2519-25 (1993) BindingDB Entry DOI: 10.7270/Q2QF8RZ9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50044454 (8-(3-Phenoxy-propyl)-1-phenyl-1,3,8-triaza-spiro[4...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CCCOc2ccccc2)CC1 Show InChI InChI=1S/C22H27N3O2/c26-21-22(25(18-23-21)19-8-3-1-4-9-19)12-15-24(16-13-22)14-7-17-27-20-10-5-2-6-11-20/h1-6,8-11H,7,12-18H2,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Tested for binding affinity against 5-hydroxytryptamine 1A receptor from rat frontal cortical regions using [3H]-8-OH-DPAT as radioligand				J Med Chem 36: 2519-25 (1993) BindingDB Entry DOI: 10.7270/Q2QF8RZ9
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50044454 (8-(3-Phenoxy-propyl)-1-phenyl-1,3,8-triaza-spiro[4...) Show SMILES O=C1NCN(c2ccccc2)C11CCN(CCCOc2ccccc2)CC1 Show InChI InChI=1S/C22H27N3O2/c26-21-22(25(18-23-21)19-8-3-1-4-9-19)12-15-24(16-13-22)14-7-17-27-20-10-5-2-6-11-20/h1-6,8-11H,7,12-18H2,(H,23,26)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Tested for binding affinity against 5-hydroxytryptamine 1C receptor from rat frontal cortical regions using [3H]-mesulergine as radioligand				J Med Chem 36: 2519-25 (1993) BindingDB Entry DOI: 10.7270/Q2QF8RZ9
					More data for this Ligand-Target Pair