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BDBM50044579 CHEMBL3341906

SMILES: FC(F)(F)c1cc(cc(c1)C(F)(F)F)N1C(=O)c2cnc(Cl)nc2C1=O

InChI Key: InChIKey=COBHXBXROORIBO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50044579   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transcription factor AP-1


(Homo sapiens (Human))		BDBM50044579
PNG
(CHEMBL3341906)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)N1C(=O)c2cnc(Cl)nc2C1=O
Show InChI InChI=1S/C14H4ClF6N3O2/c15-12-22-4-8-9(23-12)11(26)24(10(8)25)7-2-5(13(16,17)18)1-6(3-7)14(19,20)21/h1-4H
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Article
PubMed
n/an/a 9.40E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assay

J Med Chem 57: 6930-48 (2014)


Article DOI: 10.1021/jm5004733
BindingDB Entry DOI: 10.7270/Q2222WDT
More data for this
Ligand-Target Pair