BDBM50044879 (4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one::8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-hexahydro-2H-benzo[f]quinolin-3-one::CHEMBL29166::LY-266111
SMILES: CN1[C@@H]2CCc3cc(Cl)ccc3[C@@]2(C)CCC1=O
InChI Key: InChIKey=KTBSRSVHEOTHLD-UKRRQHHQSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of recombinant human Steroid 5-alpha-reductase type I | Bioorg Med Chem Lett 4: 1365-1368 (1994) Article DOI: 10.1016/S0960-894X(01)80363-2 BindingDB Entry DOI: 10.7270/Q26M381K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid 5-alpha-reductase (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of type-1 human steroid 5-alpha-reductase | Bioorg Med Chem Lett 6: 481-484 (1996) Article DOI: 10.1016/0960-894X(96)00054-6 BindingDB Entry DOI: 10.7270/Q2BZ661K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of type-1 human steroid 5-alpha-reductase | Bioorg Med Chem Lett 6: 481-484 (1996) Article DOI: 10.1016/0960-894X(96)00054-6 BindingDB Entry DOI: 10.7270/Q2BZ661K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of recombinant human Steroid 5-alpha-reductase type I | Bioorg Med Chem Lett 4: 1365-1368 (1994) Article DOI: 10.1016/S0960-894X(01)80363-2 BindingDB Entry DOI: 10.7270/Q26M381K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Apparent inhibition constant towards human Steroid 5-alpha-reductase type I | Bioorg Med Chem Lett 4: 2327-2330 (1994) Article DOI: 10.1016/0960-894X(94)85034-8 BindingDB Entry DOI: 10.7270/Q25Q4X8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid 5-alpha-reductase (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of recombinant human Steroid 5-alpha-reductase type 2 | Bioorg Med Chem Lett 4: 1365-1368 (1994) Article DOI: 10.1016/S0960-894X(01)80363-2 BindingDB Entry DOI: 10.7270/Q26M381K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid 5-alpha-reductase (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibition of recombinant human Steroid 5-alpha-reductase type 2 | Bioorg Med Chem Lett 4: 1365-1368 (1994) Article DOI: 10.1016/S0960-894X(01)80363-2 BindingDB Entry DOI: 10.7270/Q26M381K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Steroid 5-alpha-reductase (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Apparent inhibition constant towards human Steroid 5-alpha-reductase type 2 | Bioorg Med Chem Lett 4: 2327-2330 (1994) Article DOI: 10.1016/0960-894X(94)85034-8 BindingDB Entry DOI: 10.7270/Q25Q4X8P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description In vitro inhibition of DHT production in Hs 68 (human genital fibroblast) cells. | J Med Chem 36: 421-3 (1993) BindingDB Entry DOI: 10.7270/Q2T43TQX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Canterbury Curated by ChEMBL | Assay Description In vitro inhibitory activity against Steroid 5-alpha-reductase type I | Bioorg Med Chem Lett 10: 1909-11 (2001) BindingDB Entry DOI: 10.7270/Q2M044PB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5α-Reductase 1 (5α-R1) (Homo sapiens (Human)) | BDBM50044879 ((4aR,10bR)-8-Chloro-4,10b-dimethyl-1,4,4a,5,6,10b-...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description In vitro inhibitory concentration required to inhibit Steroid 5-alpha-reductase type 1 in cultured Hs 68 human foreskin fibroblast cells | Bioorg Med Chem Lett 3: 1157-1162 (1993) Article DOI: 10.1016/S0960-894X(00)80306-6 BindingDB Entry DOI: 10.7270/Q2VD70NP | |||||||||||
More data for this Ligand-Target Pair |