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BDBM50045843 8-M-PDOT::CHEMBL99377::N-(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propionamide

SMILES: CCC(=O)NC1CCc2cccc(OC)c2C1

InChI Key: InChIKey=RVIGBTUDFAGRTQ-UHFFFAOYSA-N

Data: 4 KI 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50045843
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Melatonin (RABBIT)	BDBM50045843 (8-M-PDOT \| CHEMBL99377 \| N-(8-Methoxy-1,2,3,4-tetr...) Show SMILES CCC(=O)NC1CCc2cccc(OC)c2C1 Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by PDSP K_i Database									Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF
Northwestern University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM50045843 (8-M-PDOT \| CHEMBL99377 \| N-(8-Methoxy-1,2,3,4-tetr...) Show SMILES CCC(=O)NC1CCc2cccc(OC)c2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by PDSP K_i Database									Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF
Northwestern University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Melatonin receptor (Gallus gallus-Chick)	BDBM50045843 (8-M-PDOT \| CHEMBL99377 \| N-(8-Methoxy-1,2,3,4-tetr...) Show SMILES CCC(=O)NC1CCc2cccc(OC)c2C1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	7.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Binding affinity to compete for 2-[125I]iodomelatonin binding to chicken retinal membranes				J Med Chem 36: 2891-8 (1993) Article DOI: 10.1021/jm00072a008 BindingDB Entry DOI: 10.7270/Q2HT2RJK
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM50045843 (8-M-PDOT \| CHEMBL99377 \| N-(8-Methoxy-1,2,3,4-tetr...) Show SMILES CCC(=O)NC1CCc2cccc(OC)c2C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	60.2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Northwestern University Curated by PDSP K_i Database									Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF
Northwestern University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Melatonin receptor (Homo sapiens (Human))	BDBM50045843 (8-M-PDOT \| CHEMBL99377 \| N-(8-Methoxy-1,2,3,4-tetr...) Show SMILES CCC(=O)NC1CCc2cccc(OC)c2C1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.480	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina.				J Med Chem 36: 2891-8 (1993) Article DOI: 10.1021/jm00072a008 BindingDB Entry DOI: 10.7270/Q2HT2RJK
University of Groningen Curated by ChEMBL					More data for this Ligand-Target Pair