BDBM50046268 6-Bromomethylene-3-naphthalen-1-yl-tetrahydro-pyran-2-one::6-[1-Bromo-meth-(E)-ylidene]-3-naphthalen-1-yl-tetrahydro-pyran-2-one::BTNP::CHEMBL6206

SMILES: Br\C=C1/CCC(C(=O)O1)c1cccc2ccccc12

InChI Key: InChIKey=BYUCSFWXCMTYOI-ZRDIBKRKSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50046268   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium-independent phospholipase A2 (Homo sapiens (Human))	BDBM50046268 (6-Bromomethylene-3-naphthalen-1-yl-tetrahydro-pyra...) Show SMILES Br\C=C1/CCC(C(=O)O1)c1cccc2ccccc12 Show InChI InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2 .				J Med Chem 36: 95-100 (1993) BindingDB Entry DOI: 10.7270/Q22J69XV
					More data for this Ligand-Target Pair
Calcium-independent phospholipase A2 (Homo sapiens (Human))	BDBM50046268 (6-Bromomethylene-3-naphthalen-1-yl-tetrahydro-pyra...) Show SMILES Br\C=C1/CCC(C(=O)O1)c1cccc2ccccc12 Show InChI InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
Washington University School of Medicine Curated by ChEMBL					Assay Description Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2 .				J Med Chem 36: 95-100 (1993) BindingDB Entry DOI: 10.7270/Q22J69XV
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat))	BDBM50046268 (6-Bromomethylene-3-naphthalen-1-yl-tetrahydro-pyra...) Show SMILES Br\C=C1/CCC(C(=O)O1)c1cccc2ccccc12 Show InChI InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibition of FAAH in rat brain assessed as hydrolysis of anandamide				J Med Chem 51: 7327-43 (2009) Article DOI: 10.1021/jm800311k BindingDB Entry DOI: 10.7270/Q2J67HT8
					More data for this Ligand-Target Pair
Fatty-acid amide hydrolase 1 (Homo sapiens (Human))	BDBM50046268 (6-Bromomethylene-3-naphthalen-1-yl-tetrahydro-pyra...) Show SMILES Br\C=C1/CCC(C(=O)O1)c1cccc2ccccc12 Show InChI InChI=1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Catholique de Louvain Curated by ChEMBL					Assay Description Irreversible inhibition of fatty acid amide hydrolase				J Med Chem 48: 5059-87 (2005) Article DOI: 10.1021/jm058183t BindingDB Entry DOI: 10.7270/Q2J96753
					More data for this Ligand-Target Pair