BDBM50046373 CHEMBL108670::{1-(3,4-Dichloro-phenyl)-2-[2-(1-formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester

SMILES: CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=JLNWZEIIEIIPES-OBONGRFPSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50046373   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Plasminogen (Homo sapiens (Human))	BDBM50046373 (CHEMBL108670 | {1-(3,4-Dichloro-phenyl)-2-[2-(1-fo...) Show SMILES CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H34Cl2N6O5/c1-24(2,3)37-23(36)31-19(14-8-9-16(25)17(26)12-14)21(35)32-11-5-7-18(32)20(34)30-15(13-33)6-4-10-29-22(27)28/h8-9,12-13,15,18-19H,4-7,10-11H2,1-3H3,(H,30,34)(H,31,36)(H4,27,28,29)/t15?,18-,19?/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against plasmin				J Med Chem 36: 314-9 (1993) BindingDB Entry DOI: 10.7270/Q2930S8J
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM50046373 (CHEMBL108670 | {1-(3,4-Dichloro-phenyl)-2-[2-(1-fo...) Show SMILES CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H34Cl2N6O5/c1-24(2,3)37-23(36)31-19(14-8-9-16(25)17(26)12-14)21(35)32-11-5-7-18(32)20(34)30-15(13-33)6-4-10-29-22(27)28/h8-9,12-13,15,18-19H,4-7,10-11H2,1-3H3,(H,30,34)(H,31,36)(H4,27,28,29)/t15?,18-,19?/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Compound was tested in vitro for inhibitory activity against t-PA (tissue plasminogen activator)				J Med Chem 36: 314-9 (1993) BindingDB Entry DOI: 10.7270/Q2930S8J
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM50046373 (CHEMBL108670 | {1-(3,4-Dichloro-phenyl)-2-[2-(1-fo...) Show SMILES CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H34Cl2N6O5/c1-24(2,3)37-23(36)31-19(14-8-9-16(25)17(26)12-14)21(35)32-11-5-7-18(32)20(34)30-15(13-33)6-4-10-29-22(27)28/h8-9,12-13,15,18-19H,4-7,10-11H2,1-3H3,(H,30,34)(H,31,36)(H4,27,28,29)/t15?,18-,19?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against factor Xa				J Med Chem 36: 314-9 (1993) BindingDB Entry DOI: 10.7270/Q2930S8J
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50046373 (CHEMBL108670 | {1-(3,4-Dichloro-phenyl)-2-[2-(1-fo...) Show SMILES CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H34Cl2N6O5/c1-24(2,3)37-23(36)31-19(14-8-9-16(25)17(26)12-14)21(35)32-11-5-7-18(32)20(34)30-15(13-33)6-4-10-29-22(27)28/h8-9,12-13,15,18-19H,4-7,10-11H2,1-3H3,(H,30,34)(H,31,36)(H4,27,28,29)/t15?,18-,19?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against thrombin				J Med Chem 36: 314-9 (1993) BindingDB Entry DOI: 10.7270/Q2930S8J
					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50046373 (CHEMBL108670 | {1-(3,4-Dichloro-phenyl)-2-[2-(1-fo...) Show SMILES CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H34Cl2N6O5/c1-24(2,3)37-23(36)31-19(14-8-9-16(25)17(26)12-14)21(35)32-11-5-7-18(32)20(34)30-15(13-33)6-4-10-29-22(27)28/h8-9,12-13,15,18-19H,4-7,10-11H2,1-3H3,(H,30,34)(H,31,36)(H4,27,28,29)/t15?,18-,19?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against trypsin				J Med Chem 36: 314-9 (1993) BindingDB Entry DOI: 10.7270/Q2930S8J
					More data for this Ligand-Target Pair