BDBM50047088 2-{2-[4-(3H-Inden-1-ylmethyl)-piperidin-1-yl]-ethyl}-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide::CHEMBL416544
SMILES: O=S1(=O)N(CCN2CCC(CC3=CCc4ccccc34)CC2)c2cccc3cccc1c23
InChI Key: InChIKey=LUENHUWMNYJIAU-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50047088 (2-{2-[4-(3H-Inden-1-ylmethyl)-piperidin-1-yl]-ethy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Vitry-Alfortville Curated by ChEMBL | Assay Description Binding affinity at dopamine receptor D2 by the inhibition of binding to [3H]-spiperone in rat striatal membranes | J Med Chem 36: 1194-202 (1993) BindingDB Entry DOI: 10.7270/Q2MC8Z3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50047088 (2-{2-[4-(3H-Inden-1-ylmethyl)-piperidin-1-yl]-ethy...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Vitry-Alfortville Curated by ChEMBL | Assay Description Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptake | J Med Chem 36: 1194-202 (1993) BindingDB Entry DOI: 10.7270/Q2MC8Z3Z | |||||||||||
More data for this Ligand-Target Pair |