BDBM50049146 CHEMBL3315251
SMILES: OC(=O)Cc1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1
InChI Key: InChIKey=CJQFUKZLNADPJB-UHFFFAOYSA-N
Data: 2 IC50
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50049146 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50049146
(CHEMBL3315251)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C20H17ClN4O2/c21-15-3-1-2-14(11-15)19-23-18(13-6-7-13)24-20(25-19)22-16-8-4-12(5-9-16)10-17(26)27/h1-5,8-9,11,13H,6-7,10H2,(H,26,27)(H,22,23,24,25) | PDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4D |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50049146
(CHEMBL3315251)Show SMILES OC(=O)Cc1ccc(Nc2nc(nc(n2)-c2cccc(Cl)c2)C2CC2)cc1 Show InChI InChI=1S/C20H17ClN4O2/c21-15-3-1-2-14(11-15)19-23-18(13-6-7-13)24-20(25-19)22-16-8-4-12(5-9-16)10-17(26)27/h1-5,8-9,11,13H,6-7,10H2,(H,26,27)(H,22,23,24,25) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 237 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Illinois University
Curated by ChEMBL
| Assay Description Inhibition of human PDE4B |
Bioorg Med Chem Lett 24: 4031-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.002 BindingDB Entry DOI: 10.7270/Q2KD20KD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |