BDBM50049189 3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-ylmethyl)-phenyl]-5-isobutyl-thiophene-2-sulfonic acid butyloxycarbonylamide(L-162313)::CHEMBL288174::L-162313::butyl 3-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)-5-isobutylthiophen-2-ylsulfonylcarbamate
SMILES: CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc23)cc1
InChI Key: InChIKey=RINPELQWLUGERM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AGTR1 (RAT) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [125]Ang2 from AT1 receptor in rat liver membrane | Bioorg Med Chem 16: 6841-9 (2008) Article DOI: 10.1016/j.bmc.2008.05.066 BindingDB Entry DOI: 10.7270/Q22F7N7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (Sus scrofa) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [125]Ang2 from AT2 receptor in pig uterus membrane | Bioorg Med Chem 16: 6841-9 (2008) Article DOI: 10.1016/j.bmc.2008.05.066 BindingDB Entry DOI: 10.7270/Q22F7N7C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor | J Med Chem 47: 5995-6008 (2004) Article DOI: 10.1021/jm049715t BindingDB Entry DOI: 10.7270/Q29Z95PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Binding affinity at Angiotensin II receptor, type 2 in pig uterus myometrial membranes by [125I]-Ang II displacement. | J Med Chem 47: 1536-46 (2004) Article DOI: 10.1021/jm031031i BindingDB Entry DOI: 10.7270/Q2NS0TBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (AT-1) type-1 (RAT) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) Curated by ChEMBL | Assay Description Displacement of [125I]Ang II from AT1 receptor in rat liver membranes | J Med Chem 63: 1978-1995 (2020) Article DOI: 10.1021/acs.jmedchem.9b01780 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT2 (RAT) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [125I]angiotensin 2 from rat AT2 receptor expressed in african green monkey COS7 cells after 24 hrs | Bioorg Med Chem 18: 4570-90 (2010) Article DOI: 10.1016/j.bmc.2010.03.064 BindingDB Entry DOI: 10.7270/Q2VD70F0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [125I]-Ang II from pig uterus membrane angiotensin II type 2 (AT2) receptor | J Med Chem 47: 5995-6008 (2004) Article DOI: 10.1021/jm049715t BindingDB Entry DOI: 10.7270/Q29Z95PH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibition of Angiotensin II receptor, type 1 | J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Inhibitory concentration against towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial ... | J Med Chem 47: 1536-46 (2004) Article DOI: 10.1021/jm031031i BindingDB Entry DOI: 10.7270/Q2NS0TBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (Homo sapiens (Human)) | BDBM50049189 (3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
DuPont Merck Pharmaceutical Company Curated by ChEMBL | Assay Description Inhibition of Angiotensin II receptor, type 2 | J Med Chem 39: 625-56 (1996) Article DOI: 10.1021/jm9504722 BindingDB Entry DOI: 10.7270/Q29P3299 | |||||||||||
More data for this Ligand-Target Pair |