BindingDB PrimarySearch

BDBM50049257 Azepan-(2Z)-ylideneamine::CHEMBL315857::CHEMBL543752

SMILES: NC1=NCCCCC1

InChI Key: InChIKey=GTLJSJNKRLFVSJ-UHFFFAOYSA-N

Data: 10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50049257
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Curated by ChEMBL					Assay Description Inhibition of endothelial nitric oxide synthase				Bioorg Med Chem Lett 11: 2651-3 (2001) BindingDB Entry DOI: 10.7270/Q24T6HPK
Pharmacia Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Curated by ChEMBL					Assay Description Inhibition of Neuronal nitric oxide synthase				Bioorg Med Chem Lett 11: 2651-3 (2001) BindingDB Entry DOI: 10.7270/Q24T6HPK
Pharmacia Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Curated by ChEMBL					Assay Description Inhibition of inducible nitric oxide synthase				Bioorg Med Chem Lett 11: 2651-3 (2001) BindingDB Entry DOI: 10.7270/Q24T6HPK
Pharmacia Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
G. D. Searle Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against human Neuronal nitric oxide synthase				J Med Chem 39: 669-72 (1996) Article DOI: 10.1021/jm950766n BindingDB Entry DOI: 10.7270/Q261110M
G. D. Searle Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibitory activity evaluated from soluble cell extract of human endothelia constitutive enzyme (Endothelial nitric oxide synthase) and partially pur...				J Med Chem 41: 1361-6 (1998) Article DOI: 10.1021/jm9704715 BindingDB Entry DOI: 10.7270/Q2348M29
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, endothelial (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
G. D. Searle Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against human Endothelial nitric oxide synthase				J Med Chem 39: 669-72 (1996) Article DOI: 10.1021/jm950766n BindingDB Entry DOI: 10.7270/Q261110M
G. D. Searle Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric Oxide Synthase, inducible (Mus musculus (mouse))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description The ability of compound to inhibit mouse Inducible nitric oxide synthase in LPS stimulated mouse RAW cells was determined				J Med Chem 41: 1361-6 (1998) Article DOI: 10.1021/jm9704715 BindingDB Entry DOI: 10.7270/Q2348M29
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibitory activity evaluated for soluble cell extract of human Inducible nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...				J Med Chem 41: 1361-6 (1998) Article DOI: 10.1021/jm9704715 BindingDB Entry DOI: 10.7270/Q2348M29
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, brain (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibitory activity evaluated from soluble cell extract of human Neuronal nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...				J Med Chem 41: 1361-6 (1998) Article DOI: 10.1021/jm9704715 BindingDB Entry DOI: 10.7270/Q2348M29
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Homo sapiens (Human))	BDBM50049257 (Azepan-(2Z)-ylideneamine \| CHEMBL315857 \| CHEMBL54...) Show SMILES NC1=NCCCCC1 \|t:1\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
G. D. Searle Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against human inducible nitric oxide synthase				J Med Chem 39: 669-72 (1996) Article DOI: 10.1021/jm950766n BindingDB Entry DOI: 10.7270/Q261110M
G. D. Searle Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair