BDBM50049315 CHEMBL423623::N-[1-{[Acetyl-(2-chloro-benzyl)-amino]-methyl}-2-(1H-indol-3-yl)-ethyl]-2-[1,4']bipiperidinyl-1'-yl-acetamide

SMILES: CC(=O)N(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(CC1)N1CCCCC1)Cc1ccccc1Cl

InChI Key: InChIKey=CBCYNWHALJOBSG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50049315   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neurokinin 1 receptor (Homo sapiens (Human))	BDBM50049315 (CHEMBL423623 | N-[1-{[Acetyl-(2-chloro-benzyl)-ami...) Show SMILES CC(=O)N(CC(Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(CC1)N1CCCCC1)Cc1ccccc1Cl Show InChI InChI=1S/C32H42ClN5O2/c1-24(39)38(21-25-9-3-5-11-30(25)33)22-27(19-26-20-34-31-12-6-4-10-29(26)31)35-32(40)23-36-17-13-28(14-18-36)37-15-7-2-8-16-37/h3-6,9-12,20,27-28,34H,2,7-8,13-19,21-23H2,1H3,(H,35,40)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand				J Med Chem 39: 736-48 (1996) Article DOI: 10.1021/jm950616c BindingDB Entry DOI: 10.7270/Q20864C7
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