BDBM50049441 CHEMBL3356470
SMILES: C[C@H]1N2C(COc3cc(C)c(NC4CNC4)cc23)=NNC1=O
InChI Key: InChIKey=YWULJUISHNTGOC-SECBINFHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein kinase C alpha type (Homo sapiens (Human)) | BDBM50049441 (CHEMBL3356470) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center Curated by ChEMBL | Assay Description Inhibition of human recombinant PKCalpha expressed in Sf21 cells using Bio-cdc peptide substrate and ATP after 60 mins by time-resolved fluorescence ... | J Med Chem 58: 222-36 (2015) Article DOI: 10.1021/jm500669m BindingDB Entry DOI: 10.7270/Q22F7Q2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PKC alpha and beta-2 (Homo sapiens (Human)) | BDBM50049441 (CHEMBL3356470) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center Curated by ChEMBL | Assay Description Inhibition of human recombinant PKCbeta expressed in Sf21 cells using Bio-cdc peptide substrate and ATP after 60 mins by time-resolved fluorescence i... | J Med Chem 58: 222-36 (2015) Article DOI: 10.1021/jm500669m BindingDB Entry DOI: 10.7270/Q22F7Q2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C theta type (Homo sapiens (Human)) | BDBM50049441 (CHEMBL3356470) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center Curated by ChEMBL | Assay Description Inhibition of human recombinant PKCtheta expressed in Sf21 cells using Bio-cdc peptide substrate and ATP after 60 mins by time-resolved fluorescence ... | J Med Chem 58: 222-36 (2015) Article DOI: 10.1021/jm500669m BindingDB Entry DOI: 10.7270/Q22F7Q2Z | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein kinase C gamma (Homo sapiens (Human)) | BDBM50049441 (CHEMBL3356470) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center Curated by ChEMBL | Assay Description Inhibition of human recombinant PKCgamma expressed in Sf21 cells using Bio-cdc peptide substrate and ATP after 60 mins by time-resolved fluorescence ... | J Med Chem 58: 222-36 (2015) Article DOI: 10.1021/jm500669m BindingDB Entry DOI: 10.7270/Q22F7Q2Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C delta type (Homo sapiens (Human)) | BDBM50049441 (CHEMBL3356470) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center Curated by ChEMBL | Assay Description Inhibition of human recombinant PKCdelta expressed in Sf21 cells using Bio-cdc peptide substrate and ATP after 60 mins by time-resolved fluorescence ... | J Med Chem 58: 222-36 (2015) Article DOI: 10.1021/jm500669m BindingDB Entry DOI: 10.7270/Q22F7Q2Z | |||||||||||
More data for this Ligand-Target Pair |