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BDBM50049748 (2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioic acid::2-Amino-4-(4,4-diphenyl-butyl)-pentanedioic acid::CHEMBL39338
SMILES: N[C@@H](C[C@H](CCCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
InChI Key: InChIKey=DWLOVDOPFJPWNE-HKUYNNGSSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3). | J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Antagonist potency against cloned Metabotropic glutamate receptor 2 | J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Agonist potency against cloned human metabotropic glutamate receptor 1 | J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8). | J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 7 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7). | J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Agonist potency against cloned metabotropic glutamate receptor 5 | J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy Curated by ChEMBL | Assay Description Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4) | J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 7 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Tested for agonist activity in non-neuronal cells (RGT) expressing human mGlu7a receptor by measuring L-AP4 (1000 uM of forskolin (15 microM)-stimula... | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 5 by measuring ACPD (100 uM)-stimulated phos... | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Parc Club Orsay Université Curated by ChEMBL | Assay Description Inhibitory activity of the compound against human Metabotropic glutamate receptor 2 | J Med Chem 42: 1546-55 (1999) Article DOI: 10.1021/jm980571q BindingDB Entry DOI: 10.7270/Q27H1HRD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 3 expressed in RGT cells. | Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 2 expressed in RGT cells. | Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 4 expressed in RGT cells. | Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description In vitro antagonist activity at recombinant Metabotropic glutamate receptor 8 expressed in RGT cells. | Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description In vitro antagonist activity at recombinant Metabotropic glutamate receptor 5 expressed in RGT cells. | Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description In vitro antagonist activity at recombinant human Metabotropic glutamate receptor 1 expressed in RGT cells. | Bioorg Med Chem Lett 8: 1985-90 (1999) BindingDB Entry DOI: 10.7270/Q2K35V5D | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 3 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 3 by measuring ACPD (3 uM) induced inhibitio... | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 8 by measuring L-AP4 (0.3 uM of forskolin) (... | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 2 by measuring ACPD (3 uM) induced inhibitio... | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 4 by measuring L-AP4 (3 uM) induced inhibiti... | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutamate receptor ionotropic, kainate 3 (Rattus norvegicus) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Binding affinity against Ionotropic glutamate receptor using [3H]- CGS-19755 displacement from rat forebrain preparations | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 2 (Rattus norvegicus) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Neurochimie du CNRS Curated by ChEMBL | Assay Description Compound was tested for its ability to displace metabotropic glutamate binding to rat brain membranes using [3H]glutamate radioligand. | J Med Chem 39: 814-6 (1996) Article DOI: 10.1021/jm9508144 BindingDB Entry DOI: 10.7270/Q2P55R7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Glutamate receptor ionotropic, kainate 3 (Rattus norvegicus) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.47E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Binding affinity against Ionotropic glutamate receptor using [3H]- CGS-19755 displacement from rat forebrain preparations | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50049748 ((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Centro de Investigación Lilly Curated by ChEMBL | Assay Description Tested for agonist activity in non-neuronal cells (RGT) expressing human Metabotropic glutamate receptor 1 by measuring ACPD (100 uM)-stimulated phos... | Bioorg Med Chem Lett 8: 765-70 (1999) BindingDB Entry DOI: 10.7270/Q2T152SF | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
