null

SMILES: Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1

InChI Key: InChIKey=YTYOOWFUEIQRHQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50050165   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50050165 (4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...) Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex				J Med Chem 39: 1220-6 (1996) Article DOI: 10.1021/jm9504767 BindingDB Entry DOI: 10.7270/Q28K7855
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50050165 (4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...) Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	39.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex				J Med Chem 39: 1220-6 (1996) Article DOI: 10.1021/jm9504767 BindingDB Entry DOI: 10.7270/Q28K7855
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50050165 (4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...) Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bioprojet-Biotech Curated by ChEMBL					Assay Description Antagonist activity at H3 receptor (unknown origin)				Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50050165 (4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...) Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex				J Med Chem 39: 1220-6 (1996) Article DOI: 10.1021/jm9504767 BindingDB Entry DOI: 10.7270/Q28K7855
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50050165 (4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...) Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	118	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bioprojet-Biotech Curated by ChEMBL					Assay Description Antagonist activity at human H4 receptor expressed in CHO cells co-expressing Galphai2 assessed as inhibition of imetit-induced GTPgamma[35S] binding...				Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50050165 (4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...) Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	118	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bioprojet-Biotech Curated by ChEMBL					Assay Description Effective concentration for activation of RNase L				Eur J Med Chem 125: 565-572 (2017) Article DOI: 10.1016/j.ejmech.2016.09.074 BindingDB Entry DOI: 10.7270/Q20C4Z66
					More data for this Ligand-Target Pair