BDBM50050462 3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-indole::CHEMBL268799
SMILES: Clc1ccc(cc1)N1CCN(Cc2c[nH]c3ccccc23)CC1
InChI Key: InChIKey=NRWWWLAGZMNIDV-UHFFFAOYSA-N
Data: 7 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50050462 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-in...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Erlangen-N£rnberg Curated by ChEMBL | Assay Description Binding affinity evaluated for the displacement of [3H]spiperone against human dopamine receptor D4 | Bioorg Med Chem Lett 9: 97-102 (1999) BindingDB Entry DOI: 10.7270/Q20Z73SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50050462 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-in...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards cloned human Dopamine receptor D4 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligand | J Med Chem 39: 1941-2 (1996) Article DOI: 10.1021/jm9600712 BindingDB Entry DOI: 10.7270/Q2MW2G6D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50050462 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 71 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards cloned human Dopamine receptor D2 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligand | J Med Chem 39: 1941-2 (1996) Article DOI: 10.1021/jm9600712 BindingDB Entry DOI: 10.7270/Q2MW2G6D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50050462 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-in...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL | Assay Description Binding affinity towards cloned human Dopamine receptor D3 stably expressed in CHO cells was evaluated using [3H]-spiperone as radioligand | J Med Chem 39: 1941-2 (1996) Article DOI: 10.1021/jm9600712 BindingDB Entry DOI: 10.7270/Q2MW2G6D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (BOVINE) | BDBM50050462 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-in...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Erlangen-N£rnberg Curated by ChEMBL | Assay Description Binding affinity was evaluated for the displacement of [3H]spiperone against bovine Dopamine receptor D2 | Bioorg Med Chem Lett 9: 97-102 (1999) BindingDB Entry DOI: 10.7270/Q20Z73SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DRD1 (BOVINE) | BDBM50050462 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-in...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Erlangen-N£rnberg Curated by ChEMBL | Assay Description Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1 | Bioorg Med Chem Lett 9: 97-102 (1999) BindingDB Entry DOI: 10.7270/Q20Z73SG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50050462 (3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-in...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Erlangen-N£rnberg Curated by ChEMBL | Assay Description Binding affinity evaluated for the displacement of [3H]-spiperone against human dopamine receptor D3 | Bioorg Med Chem Lett 9: 97-102 (1999) BindingDB Entry DOI: 10.7270/Q20Z73SG | |||||||||||
More data for this Ligand-Target Pair |