BindingDB PrimarySearch

BDBM50050517 Boronic acid derivative::CHEMBL305170::N-alkyl Gly-boro-Pro derivative

SMILES: CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O

InChI Key: InChIKey=FKCMADOPPWWGNZ-JGVFFNPUSA-N

Data: 8 IC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50050517
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Fibroblast activation protein alpha (Homo sapiens (Human))	BDBM50050517 (Boronic acid derivative \| CHEMBL305170 \| N-alkyl G...) Show SMILES CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
ActivX Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against human FAP using Lys-Pro-AMC in fluorometric assay				Bioorg Med Chem Lett 15: 4239-42 (2005) Article DOI: 10.1016/j.bmcl.2005.06.075 BindingDB Entry DOI: 10.7270/Q2CJ8D2F
ActivX Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50050517 (Boronic acid derivative \| CHEMBL305170 \| N-alkyl G...) Show SMILES CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
ActivX Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against human DPP4 using Gly-Pro-AMC in fluorometric assay				Bioorg Med Chem Lett 15: 4239-42 (2005) Article DOI: 10.1016/j.bmcl.2005.06.075 BindingDB Entry DOI: 10.7270/Q2CJ8D2F
ActivX Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50050517 (Boronic acid derivative \| CHEMBL305170 \| N-alkyl G...) Show SMILES CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
ActivX Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibitory activity against human DPP7 using Ala-Pro-AMC in fluorometric assay				Bioorg Med Chem Lett 15: 4239-42 (2005) Article DOI: 10.1016/j.bmcl.2005.06.075 BindingDB Entry DOI: 10.7270/Q2CJ8D2F
ActivX Biosciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50050517 (Boronic acid derivative \| CHEMBL305170 \| N-alkyl G...) Show SMILES CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tufts University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human placental DPP4 at pH 2				J Med Chem 50: 2391-8 (2007) Article DOI: 10.1021/jm061321+ BindingDB Entry DOI: 10.7270/Q2NC6407
Tufts University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50050517 (Boronic acid derivative \| CHEMBL305170 \| N-alkyl G...) Show SMILES CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Compound was tested in vitro for inhibition of Dipeptidylpeptidase II				J Med Chem 39: 2087-94 (1996) Article DOI: 10.1021/jm950732f BindingDB Entry DOI: 10.7270/Q29Z95K5
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Homo sapiens (Human))	BDBM50050517 (Boronic acid derivative \| CHEMBL305170 \| N-alkyl G...) Show SMILES CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Compound was tested in vitro for inhibition of Prolyl endopeptidase				J Med Chem 39: 2087-94 (1996) Article DOI: 10.1021/jm950732f BindingDB Entry DOI: 10.7270/Q29Z95K5
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50050517 (Boronic acid derivative \| CHEMBL305170 \| N-alkyl G...) Show SMILES CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Tufts University School of Medicine Curated by ChEMBL					Assay Description Inhibition of human placental DPP4 at pH 8				J Med Chem 50: 2391-8 (2007) Article DOI: 10.1021/jm061321+ BindingDB Entry DOI: 10.7270/Q2NC6407
Tufts University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50050517 (Boronic acid derivative \| CHEMBL305170 \| N-alkyl G...) Show SMILES CC(C)[C@@H](N)C(=O)N1CCC[C@H]1B(O)O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.16E+5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description In vitro for inhibition of Dipeptidylpeptidase IV.				J Med Chem 39: 2087-94 (1996) Article DOI: 10.1021/jm950732f BindingDB Entry DOI: 10.7270/Q29Z95K5
					More data for this Ligand-Target Pair