BDBM50050584 1-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-4-propoxy-phenyl]-3-(4-fluoro-phenyl)-urea::CHEMBL42988

SMILES: CCCOc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1

InChI Key: InChIKey=DUHSRERDUDMRPS-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50050584   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 5A (Rattus norvegicus)	BDBM50050584 (1-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro-1H-pyrazolo[3...) Show SMILES CCCOc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1 Show InChI InChI=1S/C23H23FN6O3/c1-4-11-33-18-10-9-16(26-23(32)25-15-7-5-14(24)6-8-15)12-17(18)20-27-21-19(22(31)28-20)13(2)29-30(21)3/h5-10,12H,4,11H2,1-3H3,(H2,25,26,32)(H,27,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Laboratories Glaxo Wellcome Centre de Recherches Curated by ChEMBL					Assay Description Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)				J Med Chem 39: 1635-44 (1996) Article DOI: 10.1021/jm950812j BindingDB Entry DOI: 10.7270/Q2057F1T
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50050584 (1-[3-(1,3-Dimethyl-4-oxo-4,5-dihydro-1H-pyrazolo[3...) Show SMILES CCCOc1ccc(NC(=O)Nc2ccc(F)cc2)cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1 Show InChI InChI=1S/C23H23FN6O3/c1-4-11-33-18-10-9-16(26-23(32)25-15-7-5-14(24)6-8-15)12-17(18)20-27-21-19(22(31)28-20)13(2)29-30(21)3/h5-10,12H,4,11H2,1-3H3,(H2,25,26,32)(H,27,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Laboratories Glaxo Wellcome Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human				J Med Chem 39: 1635-44 (1996) Article DOI: 10.1021/jm950812j BindingDB Entry DOI: 10.7270/Q2057F1T
					More data for this Ligand-Target Pair