BDBM50050617 6-(5-Amino-2-propoxy-phenyl)-1-ethyl-3-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one::CHEMBL439923

SMILES: CCCOc1ccc(N)cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1

InChI Key: InChIKey=BVZYXQOYVZEIIL-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50050617   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 5A (Rattus norvegicus)	BDBM50050617 (6-(5-Amino-2-propoxy-phenyl)-1-ethyl-3-methyl-1,5-...) Show SMILES CCCOc1ccc(N)cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1 Show InChI InChI=1S/C17H21N5O2/c1-4-8-24-13-7-6-11(18)9-12(13)15-19-16-14(17(23)20-15)10(3)21-22(16)5-2/h6-7,9H,4-5,8,18H2,1-3H3,(H,19,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Laboratories Glaxo Wellcome Centre de Recherches Curated by ChEMBL					Assay Description Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)				J Med Chem 39: 1635-44 (1996) Article DOI: 10.1021/jm950812j BindingDB Entry DOI: 10.7270/Q2057F1T
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50050617 (6-(5-Amino-2-propoxy-phenyl)-1-ethyl-3-methyl-1,5-...) Show SMILES CCCOc1ccc(N)cc1-c1nc2n(CC)nc(C)c2c(=O)[nH]1 Show InChI InChI=1S/C17H21N5O2/c1-4-8-24-13-7-6-11(18)9-12(13)15-19-16-14(17(23)20-15)10(3)21-22(16)5-2/h6-7,9H,4-5,8,18H2,1-3H3,(H,19,20,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Laboratories Glaxo Wellcome Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human				J Med Chem 39: 1635-44 (1996) Article DOI: 10.1021/jm950812j BindingDB Entry DOI: 10.7270/Q2057F1T
					More data for this Ligand-Target Pair