BDBM50050621 1,3-Dimethyl-6-[5-(2-morpholin-4-yl-acetyl)-2-propoxy-phenyl]-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one::CHEMBL42779

SMILES: CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)C(=O)CN1CCOCC1

InChI Key: InChIKey=XWJGPHILZLOFON-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50050621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphodiesterase 5A (Rattus norvegicus)	BDBM50050621 (1,3-Dimethyl-6-[5-(2-morpholin-4-yl-acetyl)-2-prop...) Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)C(=O)CN1CCOCC1 Show InChI InChI=1S/C22H27N5O4/c1-4-9-31-18-6-5-15(17(28)13-27-7-10-30-11-8-27)12-16(18)20-23-21-19(22(29)24-20)14(2)25-26(21)3/h5-6,12H,4,7-11,13H2,1-3H3,(H,23,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
Laboratories Glaxo Wellcome Centre de Recherches Curated by ChEMBL					Assay Description Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC)				J Med Chem 39: 1635-44 (1996) Article DOI: 10.1021/jm950812j BindingDB Entry DOI: 10.7270/Q2057F1T
					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50050621 (1,3-Dimethyl-6-[5-(2-morpholin-4-yl-acetyl)-2-prop...) Show SMILES CCCOc1ccc(cc1-c1nc2n(C)nc(C)c2c(=O)[nH]1)C(=O)CN1CCOCC1 Show InChI InChI=1S/C22H27N5O4/c1-4-9-31-18-6-5-15(17(28)13-27-7-10-30-11-8-27)12-16(18)20-23-21-19(22(29)24-20)14(2)25-26(21)3/h5-6,12H,4,7-11,13H2,1-3H3,(H,23,24,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Laboratories Glaxo Wellcome Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 5 from human				J Med Chem 39: 1635-44 (1996) Article DOI: 10.1021/jm950812j BindingDB Entry DOI: 10.7270/Q2057F1T
					More data for this Ligand-Target Pair