BDBM50050790 2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(3-fluoro-phenyl)-3-methoxy-propionic acid::CHEMBL67536
SMILES: COc1cc(OC)nc(OC(C(O)=O)C(OC)(c2cccc(F)c2)c2cccc(F)c2)n1
InChI Key: InChIKey=WAZSLZZZKKHKKE-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50050790 (2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(3-flu...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BASF AG Curated by ChEMBL | Assay Description Binding affinity of the compound towards human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from CHO cells | J Med Chem 39: 2123-8 (1996) Article DOI: 10.1021/jm960274q BindingDB Entry DOI: 10.7270/Q2G44PDH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EDNRB (Homo sapiens (Human)) | BDBM50050790 (2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-3,3-bis-(3-flu...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BASF AG Curated by ChEMBL | Assay Description Binding affinity of the compound towards human Endothelin B receptor by measuring its ability to displace [125I]-ET-3 from guinea pig cerebellum | J Med Chem 39: 2123-8 (1996) Article DOI: 10.1021/jm960274q BindingDB Entry DOI: 10.7270/Q2G44PDH | |||||||||||
More data for this Ligand-Target Pair |