BDBM50051308 (3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-amine::CHEMBL306315

SMILES: Clc1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1

InChI Key: InChIKey=XOWGESNQLHDSON-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50051308   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50051308 ((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...) Show SMILES Clc1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1 Show InChI InChI=1S/C16H11ClN4/c17-10-4-3-5-11(8-10)20-15-14-12-6-1-2-7-13(12)21-16(14)19-9-18-15/h1-9H,(H2,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of EGF-stimulated tyrosine phosphorylation in A431 cells expressing EGF-R				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50051308 ((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...) Show SMILES Clc1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1 Show InChI InChI=1S/C16H11ClN4/c17-10-4-3-5-11(8-10)20-15-14-12-6-1-2-7-13(12)21-16(14)19-9-18-15/h1-9H,(H2,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Protein kinase C alpha				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50051308 ((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...) Show SMILES Clc1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1 Show InChI InChI=1S/C16H11ClN4/c17-10-4-3-5-11(8-10)20-15-14-12-6-1-2-7-13(12)21-16(14)19-9-18-15/h1-9H,(H2,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of EGFR in human A431 cells assessed as inhibition of EGF-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation m...				Bioorg Med Chem 21: 1857-64 (2013) Article DOI: 10.1016/j.bmc.2013.01.040 BindingDB Entry DOI: 10.7270/Q2NS0W97
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL (Homo sapiens (Human))	BDBM50051308 ((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...) Show SMILES Clc1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1 Show InChI InChI=1S/C16H11ClN4/c17-10-4-3-5-11(8-10)20-15-14-12-6-1-2-7-13(12)21-16(14)19-9-18-15/h1-9H,(H2,18,19,20,21)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of tyrosine kinase v-Abl				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50051308 ((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...) Show SMILES Clc1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1 Show InChI InChI=1S/C16H11ClN4/c17-10-4-3-5-11(8-10)20-15-14-12-6-1-2-7-13(12)21-16(14)19-9-18-15/h1-9H,(H2,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description In vitro inhibitory activity against epidermal growth factor receptor				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50051308 ((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...) Show SMILES Clc1cccc(Nc2ncnc3[nH]c4ccccc4c23)c1 Show InChI InChI=1S/C16H11ClN4/c17-10-4-3-5-11(8-10)20-15-14-12-6-1-2-7-13(12)21-16(14)19-9-18-15/h1-9H,(H2,18,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
CIBA Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of tyrosine kinase c-Src				J Med Chem 39: 2285-92 (1996) Article DOI: 10.1021/jm960118j BindingDB Entry DOI: 10.7270/Q2J1028B
					More data for this Ligand-Target Pair