BDBM50052357 3-Biphenyl-4-ylmethyl-1-aza-bicyclo[2.2.2]octane::3-[1'-(Biphenyl)-methyl]-quinuclidine::CHEMBL99679
SMILES: C(C1CN2CCC1CC2)c1ccc(cc1)-c1ccccc1
InChI Key: InChIKey=QBLZXWRXSWVMCP-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Farnesyltransferase, putative (Leishmania major) | BDBM50052357 (3-Biphenyl-4-ylmethyl-1-aza-bicyclo[2.2.2]octane |...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Squalene synthetase (Rattus norvegicus) | BDBM50052357 (3-Biphenyl-4-ylmethyl-1-aza-bicyclo[2.2.2]octane |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Zeneca Pharmaceuticals Curated by ChEMBL | Assay Description In vitro inhibition against rat microsomal squalene synthase (SS) | J Med Chem 39: 2971-9 (1996) Article DOI: 10.1021/jm950907l BindingDB Entry DOI: 10.7270/Q24J0D7G | |||||||||||
More data for this Ligand-Target Pair |