BindingDB PrimarySearch

BDBM50052398 (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid::(2R,4R)-APDC::2R, 4R-APDC::CHEMBL40086

SMILES: N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O

InChI Key: InChIKey=XZFMJVJDSYRWDQ-AWFVSMACSA-N

Data: 10 KI 9 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50052398
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	450	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2).				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.73E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by PDSP K_i Database									J Pharmacol Exp Ther 298: 453-60 (2001) Article DOI: 10.1016/j.bioorg.2016.02.004 BindingDB Entry DOI: 10.7270/Q2V986M2
Eli Lilly and Company Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by PDSP K_i Database									Annu Rev Pharmacol Toxicol 37: 205-37 (1997) Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH
Emory University Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned human metabotropic glutamate receptor 1				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
GRM8 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned metabotropic glutamate receptor 5				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6).				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
GRM7 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)				J Med Chem 43: 2609-45 (2000) BindingDB Entry DOI: 10.7270/Q2DZ090Q
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 6 (mGlu6) (Rattus norvegicus (Rat))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 6				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity at Metabotropic glutamate receptor 3				Bioorg Med Chem Lett 11: 1919-24 (2001) BindingDB Entry DOI: 10.7270/Q2SQ90XH
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 5				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	300	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 2				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	480	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Effective concentration required for agonistic activity at Metabotropic glutamate receptor 2				Bioorg Med Chem Lett 11: 1919-24 (2001) BindingDB Entry DOI: 10.7270/Q2SQ90XH
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Universit£ Ren£ Descartes-Paris V Curated by ChEMBL					Assay Description Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inacti...				J Med Chem 48: 2534-47 (2005) Article DOI: 10.1021/jm049092j BindingDB Entry DOI: 10.7270/Q23X87FM
Universit£ Ren£ Descartes-Paris V Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing chimeric mGluR3/1a receptor				Bioorg Med Chem Lett 9: 1721-6 (1999) BindingDB Entry DOI: 10.7270/Q2V69K37
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Rattus norvegicus)	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Agonistic activity evaluated in CHO(Chinese hamster ovary) cells expressing mGluR2 receptor				Bioorg Med Chem Lett 9: 1721-6 (1999) BindingDB Entry DOI: 10.7270/Q2V69K37
Georgetown University Medical Center Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50052398 ((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid \|...) Show SMILES N[C@]1(CN[C@H](C1)C(O)=O)C(O)=O \|r\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the agonistic activity against Metabotropic glutamate receptor 1				Bioorg Med Chem Lett 7: 601-606 (1997) Article DOI: 10.1016/S0960-894X(97)00068-1 BindingDB Entry DOI: 10.7270/Q27944QG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair