BDBM50052528 3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-ynyl]-pyridine::CHEMBL108463
SMILES: C(CN1CCC(=CC1)c1ccccc1)C#Cc1cccnc1
InChI Key: InChIKey=QNTNWSQRMBFBSH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity against Dopamine receptor D2 in CHO-K1 cells using radioligand [3H]-NPA binding assay | J Med Chem 39: 3179-87 (1996) Article DOI: 10.1021/jm950721m BindingDB Entry DOI: 10.7270/Q23N22GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity against human Dopamine receptor D3 in CHO-K1 cells using [3H]-Spiperone as radioligand | J Med Chem 39: 3179-87 (1996) Article DOI: 10.1021/jm950721m BindingDB Entry DOI: 10.7270/Q23N22GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity at Dopamine receptor D2 in rat striatal membrane by [3H]-spiperone displacement. | J Med Chem 39: 3179-87 (1996) Article DOI: 10.1021/jm950721m BindingDB Entry DOI: 10.7270/Q23N22GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Rattus norvegicus (rat)) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 37.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College Curated by ChEMBL | Assay Description Binding affinity towards dopamine receptor D2 of rat striatal membrane was determined | Bioorg Med Chem Lett 15: 2149-57 (2005) Article DOI: 10.1016/j.bmcl.2005.02.012 BindingDB Entry DOI: 10.7270/Q2RR20G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat)) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 555 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity againstserotonin 5-hydroxytryptamine 1A receptor using radioligand [3H]-8-OH-DPAT binding assay | J Med Chem 39: 3179-87 (1996) Article DOI: 10.1021/jm950721m BindingDB Entry DOI: 10.7270/Q23N22GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 676 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pomona College Curated by ChEMBL | Assay Description Binding affinity towards human dopamine receptor D4 was determined | Bioorg Med Chem Lett 15: 2149-57 (2005) Article DOI: 10.1016/j.bmcl.2005.02.012 BindingDB Entry DOI: 10.7270/Q2RR20G2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 681 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity against human Dopamine receptor D4 in CHO-K1 cells using [3H]-Spiperone as radioligand | J Med Chem 39: 3179-87 (1996) Article DOI: 10.1021/jm950721m BindingDB Entry DOI: 10.7270/Q23N22GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (RAT) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand | J Med Chem 39: 3179-87 (1996) Article DOI: 10.1021/jm950721m BindingDB Entry DOI: 10.7270/Q23N22GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50052528 (3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description In vivo Dopamine receptor D2 mitogenesis measured as [3H]-thymidine incorporation in CHO p-5 cells expressing human D2 receptors | J Med Chem 39: 3179-87 (1996) Article DOI: 10.1021/jm950721m BindingDB Entry DOI: 10.7270/Q23N22GZ | |||||||||||
More data for this Ligand-Target Pair |