BindingDB PrimarySearch

BDBM50052960 2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylsulfanyl)-thiazole-5-carboxylic acid::CHEMBL118268

SMILES: Cc1cc2c(cc1Sc1ncc(s1)C(O)=O)C(C)(C)CCC2(C)C

InChI Key: InChIKey=MFXZCSFIVCAYBX-UHFFFAOYSA-N

Data: 6 Kd 3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50052960
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Retinoid X receptor alpha (Mus musculus)	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Dissociation constant for binding to Retinoid X receptor alpha				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Retinoic acid receptor alpha (Mus musculus)	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Dissociation constant for binding to Retinoic acid receptor alpha				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Retinoic acid receptor RXR-alpha (Homo sapiens (Human))	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Transcriptional activation of Retinoid X receptor RXR alpha				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Retinoic acid receptor gamma (Mus musculus)	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Dissociation constant for binding to Retinoic acid receptor gamma				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Retinoid X receptor beta (Mus musculus)	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Dissociation constant for binding to Retinoid X receptor beta				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Retinoid X receptor gamma (Mus musculus)	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Dissociation constant for binding to Retinoid X receptor gamma				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human))	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Transcriptional activation of Retinoid X receptor RXR gamma				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Retinoid receptor (Homo sapiens (Human))	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Transcriptional activation of Retinoid X receptor RXR beta				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Retinoic acid receptor beta (Mus musculus)	BDBM50052960 (2-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
Allergan, Inc Curated by ChEMBL					Assay Description Dissociation constant for binding to Retinoic acid receptor beta				J Med Chem 39: 3556-63 (1996) Article DOI: 10.1021/jm960386h BindingDB Entry DOI: 10.7270/Q2959GNV
Allergan, Inc Curated by ChEMBL					More data for this Ligand-Target Pair