BDBM50053595 4-Chloro-Phenyl biguanide::4-Chlorophenylbiguanide::CHEMBL840::N-(4-chlorophenyl)imidodicarbonimidic diamide
SMILES: NC(=N)N=C(N)Nc1ccc(Cl)cc1
InChI Key: InChIKey=HTYFFCPFVMJTKM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor (Homo sapiens (Human)) | BDBM50053595 (4-Chloro-Phenyl biguanide | 4-Chlorophenylbiguanid...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells | J Med Chem 39: 4017-26 (1996) Article DOI: 10.1021/jm9603936 BindingDB Entry DOI: 10.7270/Q23F4NQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trace amine-associated receptor 5 (Mus musculus) | BDBM50053595 (4-Chloro-Phenyl biguanide | 4-Chlorophenylbiguanid...) | UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Agonist activity at mouse TAAR5 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assay | Eur J Med Chem 127: 781-792 (2017) BindingDB Entry DOI: 10.7270/Q2C24ZPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trace amine-associated receptor 1 (Homo sapiens (Human)) | BDBM50053595 (4-Chloro-Phenyl biguanide | 4-Chlorophenylbiguanid...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Agonist activity at human TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assay | Eur J Med Chem 127: 781-792 (2017) BindingDB Entry DOI: 10.7270/Q2C24ZPS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ITGAV/ITGB3 (Homo sapiens (Human)) | BDBM50053595 (4-Chloro-Phenyl biguanide | 4-Chlorophenylbiguanid...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.49E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Medical Sciences and Peking Union Medical College Curated by ChEMBL | Assay Description Inhibition of integrin alphavbeta3 mediated cell adhesion of human M21 cells to vitronectiin | Bioorg Med Chem Lett 16: 5878-82 (2006) Article DOI: 10.1016/j.bmcl.2006.08.061 BindingDB Entry DOI: 10.7270/Q2W66N0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trace amine-associated receptor 1 (TAAR1) (Mus musculus (Mouse)) | BDBM50053595 (4-Chloro-Phenyl biguanide | 4-Chlorophenylbiguanid...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a |
University of Genoa Curated by ChEMBL | Assay Description Agonist activity at mouse TAAR1 expressed in HEK293 cells assessed as cAMP accumulation after 20 mins by BRET assay | Eur J Med Chem 127: 781-792 (2017) BindingDB Entry DOI: 10.7270/Q2C24ZPS | |||||||||||
More data for this Ligand-Target Pair |