BDBM50053631 2-(4-Methyl-piperazin-1-yl)-quinoline::2-(4-methylpiperazin-1-yl)quinoline::CHEMBL288591
SMILES: CN1CCN(CC1)c1ccc2ccccc2n1
InChI Key: InChIKey=HOMWNUXPSJQSSU-UHFFFAOYSA-N
Data: 6 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 3A (Homo sapiens (Human)) | BDBM50053631 (2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.457 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]granisetron from 5HT3A receptor expressed in HEK293 cells after 24 hrs by scintillation counting in presence of quipazine | J Med Chem 55: 8603-14 (2012) Article DOI: 10.1021/jm300801u BindingDB Entry DOI: 10.7270/Q2RF5W5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor (Homo sapiens (Human)) | BDBM50053631 (2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University Curated by ChEMBL | Assay Description Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells | J Med Chem 39: 4017-26 (1996) Article DOI: 10.1021/jm9603936 BindingDB Entry DOI: 10.7270/Q23F4NQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50053631 (2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Ability to displace [3H]granisetron specifically bound to 5-hydroxytryptamine 3 receptor in rat cortical membrane | J Med Chem 41: 728-41 (1998) Article DOI: 10.1021/jm970645i BindingDB Entry DOI: 10.7270/Q2QV3N6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT) | BDBM50053631 (2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena Curated by ChEMBL | Assay Description Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor of rat cortical membrane | J Med Chem 42: 1556-75 (1999) Article DOI: 10.1021/jm981112s BindingDB Entry DOI: 10.7270/Q2D50NPW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM50053631 (2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S Curated by ChEMBL | Assay Description Antagonist potency against human H3 receptor in GTPgamma[S]-Assay | J Med Chem 48: 306-11 (2005) Article DOI: 10.1021/jm040873u BindingDB Entry DOI: 10.7270/Q2N0161T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine receptor (H3 and H4) (Homo sapiens (Human)) | BDBM50053631 (2-(4-Methyl-piperazin-1-yl)-quinoline | 2-(4-methy...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 6.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Amsterdam Curated by ChEMBL | Assay Description Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cells | J Med Chem 51: 2457-67 (2008) Article DOI: 10.1021/jm7014217 BindingDB Entry DOI: 10.7270/Q22V2JWW | |||||||||||
More data for this Ligand-Target Pair |