BDBM50053975 CHEMBL3319557

SMILES: Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)c1ncc(cc1-c1ccc2scnc2c1)C(O)(C(F)(F)F)C(F)(F)F

InChI Key: InChIKey=SUHDMHSOLKBDSH-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50053975   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucokinase (Mus musculus (Mouse))	BDBM50053975 (CHEMBL3319557) Show SMILES Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)c1ncc(cc1-c1ccc2scnc2c1)C(O)(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C24H20F6N6O3S2/c25-23(26,27)22(37,24(28,29)30)15-10-17(14-1-3-19-18(9-14)34-13-40-19)21(33-11-15)35-5-7-36(8-6-35)41(38,39)16-2-4-20(31)32-12-16/h1-4,9-13,37H,5-8H2,(H2,31,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Induction of GK translocation from nucleus to cytoplasm of mouse hepatocytes preincubated for 20 mins followed by glucose challenge measured after 40...				J Med Chem 57: 5949-64 (2014) Article DOI: 10.1021/jm5001979 BindingDB Entry DOI: 10.7270/Q2J67JJ3
					More data for this Ligand-Target Pair
Glucokinase/Glucokinase regulatory protein (Homo sapiens (Human))	BDBM50053975 (CHEMBL3319557) Show SMILES Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)c1ncc(cc1-c1ccc2scnc2c1)C(O)(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C24H20F6N6O3S2/c25-23(26,27)22(37,24(28,29)30)15-10-17(14-1-3-19-18(9-14)34-13-40-19)21(33-11-15)35-5-7-36(8-6-35)41(38,39)16-2-4-20(31)32-12-16/h1-4,9-13,37H,5-8H2,(H2,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP compound incubated for 20 mins prior to addition of fluorescein...				J Med Chem 57: 5949-64 (2014) Article DOI: 10.1021/jm5001979 BindingDB Entry DOI: 10.7270/Q2J67JJ3
					More data for this Ligand-Target Pair