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BDBM50054344 CHEMBL3319356::US9522881, 11a-1 L97M74::US9844535, ID 11a-1 L97M74
SMILES: Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1
InChI Key: InChIKey=WILZWITYAQZYKV-UHFFFAOYSA-N
Data: 48 IC50
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description The inhibition assays were performed at 25° C. in 50 mM 3,3-dimethylglutarate buffer, pH 7.0, containing 1 mM EDTA with an ionic strength of 0.15M ad... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB KEGG GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research Curated by ChEMBL | Assay Description Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY12... | J Med Chem 59: 7773-82 (2016) Article DOI: 10.1021/acs.jmedchem.6b00680 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hematopoietic protein-tyrosine phosphatase (HEPTP) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein phosphatase non-receptor type 3 (PTPH1) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase 1C (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| CTD phosphatase SSU72 (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase 1B (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity protein phosphatase 23 (VHZ) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor-type tyrosine-protein phosphatase gamma (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase phosphatase 5 (MKP5) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity protein phosphatase (VHR) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor-type tyrosine-protein phosphatase mu (PTPμ) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase pez (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase D (PTPd) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear proteasome inhibitor UBLCP1 (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Laforin (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity protein phosphatase CDC14A (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor-type tyrosine-protein phosphatase epsilon (PTPε) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase alpha (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein phosphatase non-receptor type 5 isoform a (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein phosphatase 2A activator (Mouse) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of LYP (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Hematopoietic protein-tyrosine phosphatase (HEPTP) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of HePTP (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein phosphatase non-receptor type 3 (PTPH1) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPH1 (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase 1C (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP1 (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| CTD phosphatase SSU72 (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of Ssu72 (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 (unknown origin) using p-nitrophenyl phosphate substrate by microplate spectrophotometry | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase 1B (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTP1B (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of LMWPTP (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity protein phosphatase 23 (VHZ) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of VHZ (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase alpha (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPalpha (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor-type tyrosine-protein phosphatase gamma (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPgamma (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mitogen-activated protein kinase phosphatase 5 (MKP5) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of MKP5 (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity protein phosphatase (VHR) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of VHR (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor-type tyrosine-protein phosphatase mu (PTPμ) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPmu (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| tyrosine-protein phosphatase non-receptor type 5 isoform a (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of STEP (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Protein-tyrosine phosphatase pez (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PEZ (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor-type tyrosine-protein phosphatase S (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPsigma (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Nuclear proteasome inhibitor UBLCP1 (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of UBLCP1 (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Laforin (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of laforin (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dual specificity protein phosphatase CDC14A (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of CDC14A (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Receptor-type tyrosine-protein phosphatase epsilon (PTPε) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPepsilon (unknown origin) | J Med Chem 57: 6594-609 (2014) Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description PTP assays were conducted as previously described in Kontaridis et al., J Biol Chem. 2006; 281:6785-6792, using para-nitrophenyl phosphate (pNPP, obt... | US Patent US9844535 (2017) BindingDB Entry DOI: 10.7270/Q2NZ89X1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description PTP assays were conducted as previously described in Kontaridis et al., J Biol Chem. 2006; 281:6785-6792, using para-nitrophenyl phosphate (pNPP, obt... | US Patent US9844535 (2017) BindingDB Entry DOI: 10.7270/Q2NZ89X1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) (Homo sapiens (Human)) | BDBM50054344 (CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University Research and Technology Corporation US Patent | Assay Description The inhibition assays were performed at 25° C. in 50 mM 3,3-dimethylglutarate buffer, pH 7.0, containing 1 mM EDTA with an ionic strength of 0.15M ad... | US Patent US9522881 (2016) BindingDB Entry DOI: 10.7270/Q2DN4402 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
