BDBM50054472 (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((R)-2-hydroxy-1-methyl-ethyl)-amide::(R)-Methanandamide::CHEMBL120526::Methanandamide
SMILES: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@H](C)CO
InChI Key: InChIKey=SQKRUBZPTNJQEM-FQPARAGTSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 17.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the presence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H... | J Med Chem 41: 5353-61 (1999) Article DOI: 10.1021/jm970257g BindingDB Entry DOI: 10.7270/Q2ZS2VNV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 17.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Displacement of [3H]CP55940 from cannabinoid CB1 receptor in rat brain membrane in presence of phenylmethanesulfonyl fluoride | Bioorg Med Chem Lett 18: 5912-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.110 BindingDB Entry DOI: 10.7270/Q22R3RGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Displacement of [3H]-CP55940 from CB1 receptor of rat cerebellar membranes by liquid scintillation counting in presence of serine protease inhibitor ... | Cell Chem Biol 56: 8224-56 (2013) Article DOI: 10.1021/jm4005626 BindingDB Entry DOI: 10.7270/Q2B859M5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Displacement of [3H]-CP-55,940 from Cannabinoid receptor 1 of rat forebrain membranes | J Med Chem 39: 4515-9 (1996) Article DOI: 10.1021/jm960152y BindingDB Entry DOI: 10.7270/Q2HH6J5K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Tested for binding affinity to Cannabinoid receptor 1 | J Med Chem 42: 896-902 (1999) Article DOI: 10.1021/jm980461j BindingDB Entry DOI: 10.7270/Q2XG9Q9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor (Rattus norvegicus (Rat)-Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Binding affinity for the cannabinoid receptor in the presence of phenylmethanesulfonyl fluoride (PMSF) was determined in rat fore brain membranes | J Med Chem 37: 1889-93 (1994) Article DOI: 10.1021/jm00038a020 BindingDB Entry DOI: 10.7270/Q2JQ13QV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor (Rattus norvegicus (Rat)-Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding affinity towards cannabinoid receptor using [3H]CP-55940 as radioligand in rat brain membrane | J Med Chem 40: 3626-34 (1997) Article DOI: 10.1021/jm9702950 BindingDB Entry DOI: 10.7270/Q261131W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor (Rattus norvegicus (Rat)-Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Binding affinity for the cannabinoid receptor in the absence of phenylmethanesulfonyl fluoride (PMSF) was determined in rat fore brain membranes | J Med Chem 37: 1889-93 (1994) Article DOI: 10.1021/jm00038a020 BindingDB Entry DOI: 10.7270/Q2JQ13QV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the absence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]... | J Med Chem 41: 5353-61 (1999) Article DOI: 10.1021/jm970257g BindingDB Entry DOI: 10.7270/Q2ZS2VNV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in presence of FAAH inhibitor PMSF by radioligand binding assay | J Med Chem 61: 8639-8657 (2018) Article DOI: 10.1021/acs.jmedchem.8b00611 BindingDB Entry DOI: 10.7270/Q2HQ42HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | J Med Chem 61: 8639-8657 (2018) Article DOI: 10.1021/acs.jmedchem.8b00611 BindingDB Entry DOI: 10.7270/Q2HQ42HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (Homo sapiens (Human)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Displacement of [3H]CP-55,940 from human CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding ass... | J Med Chem 61: 8639-8657 (2018) Article DOI: 10.1021/acs.jmedchem.8b00611 BindingDB Entry DOI: 10.7270/Q2HQ42HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor (Rattus norvegicus (Rat)-Rattus norvegicus (rat)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 585 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Binding affinity towards cannabinoid receptor using [3H]SR-141,716A as radioligand in rat brain membrane | J Med Chem 40: 3626-34 (1997) Article DOI: 10.1021/jm9702950 BindingDB Entry DOI: 10.7270/Q261131W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (MOUSE) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 815 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity for mouse spleen Cannabinoid receptor 2 | J Med Chem 39: 4515-9 (1996) Article DOI: 10.1021/jm960152y BindingDB Entry DOI: 10.7270/Q2HH6J5K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (MOUSE) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 815 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Arena Pharmaceuticals Curated by ChEMBL | Assay Description Binding affinity to mouse spleen CB2 receptor | Cell Chem Biol 56: 8224-56 (2013) Article DOI: 10.1021/jm4005626 BindingDB Entry DOI: 10.7270/Q2B859M5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (MOUSE) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 868 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Displacement of [3H]CP55940 from cannabinoid CB2 receptor in mouse spleen membrane | Bioorg Med Chem Lett 18: 5912-5 (2008) Article DOI: 10.1016/j.bmcl.2008.07.110 BindingDB Entry DOI: 10.7270/Q22R3RGB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (MOUSE) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 868 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Connecticut Curated by ChEMBL | Assay Description Binding affinity towards Cannabinoid receptor 2 from mouse spleen membranes using 0.8 nM [3H]-CP-55,940 as radioligand | J Med Chem 41: 5353-61 (1999) Article DOI: 10.1021/jm970257g BindingDB Entry DOI: 10.7270/Q2ZS2VNV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 2 (MOUSE) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Displacement of [3H]CP-55,940 from mouse CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding ass... | J Med Chem 61: 8639-8657 (2018) Article DOI: 10.1021/acs.jmedchem.8b00611 BindingDB Entry DOI: 10.7270/Q2HQ42HK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium channel protein TASK-1 (Homo sapiens (Human)) | BDBM50054472 ((5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid ((...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Talca Curated by ChEMBL | Assay Description Inhibition of human TASK1 expressed in African green monkey COS cells by whole cell patch clamp assay | J Med Chem 62: 10044-10058 (2019) Article DOI: 10.1021/acs.jmedchem.9b00248 | |||||||||||
More data for this Ligand-Target Pair |