BDBM50054644 CHEMBL3318932
SMILES: CC(C)(C)OC(=O)N[C@@H]1CNC[C@@H](C1)C(=O)N(Cc1cccc(Cl)c1Cl)C1CC1
InChI Key: InChIKey=VPHFZAIDKCROMZ-CABCVRRESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Renin (Homo sapiens (Human)) | BDBM50054644 (CHEMBL3318932) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human recombinant renin using fluorescence-quenched RE(EDANS)IHPFHLVIHTK(Dabcyl)R substrate by fluorimetric assay | ACS Med Chem Lett 5: 787-92 (2014) Article DOI: 10.1021/ml500137b BindingDB Entry DOI: 10.7270/Q2WD4279 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |