BDBM50055063 CHEMBL3323510

SMILES: OC1CCN(C1)C1CCCC2NCCN(C12)C(=O)Cc1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=RDLSULOPTIRHKK-UHFFFAOYSA-N

Data: 5 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50055063   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM50055063 (CHEMBL3323510) Show SMILES OC1CCN(C1)C1CCCC2NCCN(C12)C(=O)Cc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H27Cl2N3O2/c21-15-5-4-13(10-16(15)22)11-19(27)25-9-7-23-17-2-1-3-18(20(17)25)24-8-6-14(26)12-24/h4-5,10,14,17-18,20,23,26H,1-3,6-9,11-12H2	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysis				J Med Chem 57: 6845-60 (2014) Article DOI: 10.1021/jm500940q BindingDB Entry DOI: 10.7270/Q2G73GDP
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM50055063 (CHEMBL3323510) Show SMILES OC1CCN(C1)C1CCCC2NCCN(C12)C(=O)Cc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H27Cl2N3O2/c21-15-5-4-13(10-16(15)22)11-19(27)25-9-7-23-17-2-1-3-18(20(17)25)24-8-6-14(26)12-24/h4-5,10,14,17-18,20,23,26H,1-3,6-9,11-12H2	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysis				J Med Chem 57: 6845-60 (2014) Article DOI: 10.1021/jm500940q BindingDB Entry DOI: 10.7270/Q2G73GDP
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM50055063 (CHEMBL3323510) Show SMILES OC1CCN(C1)C1CCCC2NCCN(C12)C(=O)Cc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H27Cl2N3O2/c21-15-5-4-13(10-16(15)22)11-19(27)25-9-7-23-17-2-1-3-18(20(17)25)24-8-6-14(26)12-24/h4-5,10,14,17-18,20,23,26H,1-3,6-9,11-12H2	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Displacement of [3H]U-69593 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysis				J Med Chem 57: 6845-60 (2014) Article DOI: 10.1021/jm500940q BindingDB Entry DOI: 10.7270/Q2G73GDP
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig))	BDBM50055063 (CHEMBL3323510) Show SMILES OC1CCN(C1)C1CCCC2NCCN(C12)C(=O)Cc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H27Cl2N3O2/c21-15-5-4-13(10-16(15)22)11-19(27)25-9-7-23-17-2-1-3-18(20(17)25)24-8-6-14(26)12-24/h4-5,10,14,17-18,20,23,26H,1-3,6-9,11-12H2	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Displacement of [3H]Cl-977 from kappa opioid receptor in guinea pig brain membranes after 2 hrs by scintillation counting analysis				J Med Chem 57: 6845-60 (2014) Article DOI: 10.1021/jm500940q BindingDB Entry DOI: 10.7270/Q2G73GDP
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50055063 (CHEMBL3323510) Show SMILES OC1CCN(C1)C1CCCC2NCCN(C12)C(=O)Cc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H27Cl2N3O2/c21-15-5-4-13(10-16(15)22)11-19(27)25-9-7-23-17-2-1-3-18(20(17)25)24-8-6-14(26)12-24/h4-5,10,14,17-18,20,23,26H,1-3,6-9,11-12H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Displacement of [3H]-naloxone from human mu opioid receptor expressed in CHO-K1 cells by scintillation counting analysis				J Med Chem 57: 6845-60 (2014) Article DOI: 10.1021/jm500940q BindingDB Entry DOI: 10.7270/Q2G73GDP
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50055063 (CHEMBL3323510) Show SMILES OC1CCN(C1)C1CCCC2NCCN(C12)C(=O)Cc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H27Cl2N3O2/c21-15-5-4-13(10-16(15)22)11-19(27)25-9-7-23-17-2-1-3-18(20(17)25)24-8-6-14(26)12-24/h4-5,10,14,17-18,20,23,26H,1-3,6-9,11-12H2	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Westf£lische Wilhelms-Universit£t M£nster Curated by ChEMBL					Assay Description Agonist activity at human kappa opioid receptor expressed in HEK-293 cells assessed as stimulation of [35S]-GTPgammaS binding after 30 mins by liquid...				J Med Chem 57: 6845-60 (2014) Article DOI: 10.1021/jm500940q BindingDB Entry DOI: 10.7270/Q2G73GDP
					More data for this Ligand-Target Pair