BDBM50055629 CHEMBL62202::[(R)-1-(1-{(R)-2-Benzyloxy-1-[(R)-1-((S)-1-carbamoyl-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-cyclohexyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-carbamic acid benzyl ester

SMILES: C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(CC1CCCCC1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O

InChI Key: InChIKey=COANPFLFVMQXSD-GAJOXTLQSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50055629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat))	BDBM50055629 (CHEMBL62202 | [(R)-1-(1-{(R)-2-Benzyloxy-1-[(R)-1-...) Show SMILES C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](COCc1ccccc1)NC(=O)C(CC1CCCCC1)NC(=O)[C@@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1)C(N)=O Show InChI InChI=1S/C47H57N9O8/c1-30(42(48)57)52-43(58)39(22-34-24-50-37-20-12-11-19-36(34)37)54-46(61)41(28-63-26-32-15-7-3-8-16-32)55-44(59)38(21-31-13-5-2-6-14-31)53-45(60)40(23-35-25-49-29-51-35)56-47(62)64-27-33-17-9-4-10-18-33/h3-4,7-12,15-20,24-25,29-31,38-41,50H,2,5-6,13-14,21-23,26-28H2,1H3,(H2,48,57)(H,49,51)(H,52,58)(H,53,60)(H,54,61)(H,55,59)(H,56,62)/t30-,38?,39+,40+,41+/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	66	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against rat brain farnesyltransferase				J Med Chem 40: 192-200 (1997) Article DOI: 10.1021/jm960602m BindingDB Entry DOI: 10.7270/Q2JW8FJ4
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