Found 10 hits for monomerid = 50055864 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of mTOR (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of B-Raf (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of C-Raf (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of KDR (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of VEGFR (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein kinase FLT3
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of FLT3 (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of KIT (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50055864
(CHEMBL3326099)Show SMILES CCN(CC)CCCNc1nc(nc2ccsc12)-c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C26H29ClN6OS/c1-3-33(4-2)16-5-15-28-25-23-22(14-17-35-23)31-24(32-25)18-6-10-20(11-7-18)29-26(34)30-21-12-8-19(27)9-13-21/h6-14,17H,3-5,15-16H2,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay |
Eur J Med Chem 85: 215-27 (2014)
Article DOI: 10.1016/j.ejmech.2014.07.099 BindingDB Entry DOI: 10.7270/Q24T6M19 |
More data for this Ligand-Target Pair | |