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BDBM50056543 4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-phenyl-methyl]-N,N-diethyl-benzamide::4-[(4-Allyl-2,5-dimethyl-piperazin-1-yl)-phenyl-methyl]-N,N-diethyl-benzamide::4-[(S)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-phenyl-methyl]-N,N-diethyl-benzamide::CHEMBL153648
SMILES: CCN(CC)C(=O)c1ccc(cc1)C(N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1ccccc1
InChI Key: InChIKey=WGIDFDFAOQVAHY-SGNGHUOJSA-N
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Similars | PubMed | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement. | J Med Chem 42: 5455-63 (2000) BindingDB Entry DOI: 10.7270/Q2QJ7J0X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes. | J Med Chem 42: 5455-63 (2000) BindingDB Entry DOI: 10.7270/Q2QJ7J0X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane... | J Med Chem 42: 5455-63 (2000) BindingDB Entry DOI: 10.7270/Q2QJ7J0X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1 | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (MOUSE) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1 | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (GUINEA PIG) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity was evaluated in guinea pig ileum (GPI) preparations at Opioid receptor mu 1 | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (MOUSE) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1 | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (GUINEA PIG) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity was evaluated in guinea pig ileum (GPI) preparations at Opioid receptor mu 1 | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd. Curated by ChEMBL | Assay Description Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes | Bioorg Med Chem Lett 9: 1323-8 (1999) BindingDB Entry DOI: 10.7270/Q2PC32VS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1 | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (MOUSE) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity was evaluated in mouse vas deferens (MVD) preparations at Opioid receptor delta 1 | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (MOUSE) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity using electrically induced smooth muscle contraction of mouse vas deferens. | J Med Chem 42: 5455-63 (2000) BindingDB Entry DOI: 10.7270/Q2QJ7J0X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Opioid receptors; mu & delta (Rattus norvegicus (rat)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1 | J Med Chem 40: 695-704 (1997) Article DOI: 10.1021/jm960319n BindingDB Entry DOI: 10.7270/Q2F190DS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Mu-type opioid receptor (GUINEA PIG) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8.58E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus. | J Med Chem 42: 5455-63 (2000) BindingDB Entry DOI: 10.7270/Q2QJ7J0X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd. Curated by ChEMBL | Assay Description Binding inhibition of [3H]- -naltrindole (0.15 nM) to membranes in CHO cells expressing Opioid receptor delta 1 | Bioorg Med Chem Lett 9: 1323-8 (1999) BindingDB Entry DOI: 10.7270/Q2PC32VS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Kappa-type opioid receptor (Cavia porcellus (domestic guinea pig)) | BDBM50056543 (4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Organon Laboratories Ltd. Curated by ChEMBL | Assay Description Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes | Bioorg Med Chem Lett 9: 1323-8 (1999) BindingDB Entry DOI: 10.7270/Q2PC32VS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
