BDBM50057513 (2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one::CHEMBL267144::benzolactam-V8

SMILES: CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O

InChI Key: InChIKey=OBEJTRHPRSRHSZ-JSGCOSHPSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50057513   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50057513 ((2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5...) Show SMILES CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O Show InChI InChI=1S/C15H22N2O2/c1-10(2)14-15(19)16-12(9-18)8-11-6-4-5-7-13(11)17(14)3/h4-7,10,12,14,18H,8-9H2,1-3H3,(H,16,19)/t12-,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	334	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry Curated by ChEMBL					Assay Description Displacement of phorbol 12,13-dibutyrate (PDBU) from recombinant Protein kinase C alpha				Bioorg Med Chem Lett 9: 1371-4 (1999) BindingDB Entry DOI: 10.7270/Q2HQ3Z3K
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50057513 ((2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5...) Show SMILES CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O Show InChI InChI=1S/C15H22N2O2/c1-10(2)14-15(19)16-12(9-18)8-11-6-4-5-7-13(11)17(14)3/h4-7,10,12,14,18H,8-9H2,1-3H3,(H,16,19)/t12-,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	334	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry Curated by ChEMBL					Assay Description Displacement phorbol 12,13-dibutyrate(PDBU) binding from recombinant Protein kinase C alpha				Bioorg Med Chem Lett 11: 99-101 (2001) BindingDB Entry DOI: 10.7270/Q2XP745F
					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50057513 ((2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5...) Show SMILES CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O Show InChI InChI=1S/C15H22N2O2/c1-10(2)14-15(19)16-12(9-18)8-11-6-4-5-7-13(11)17(14)3/h4-7,10,12,14,18H,8-9H2,1-3H3,(H,16,19)/t12-,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	334	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Displacement of [3H]- PDBu from recombinant PKC alpha expressed in baculovirus				J Med Chem 40: 1316-26 (1997) Article DOI: 10.1021/jm960875h BindingDB Entry DOI: 10.7270/Q2319TZS
					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50057513 ((2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5...) Show SMILES CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O Show InChI InChI=1S/C15H22N2O2/c1-10(2)14-15(19)16-12(9-18)8-11-6-4-5-7-13(11)17(14)3/h4-7,10,12,14,18H,8-9H2,1-3H3,(H,16,19)/t12-,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from PKCdelta C1B domain				J Med Chem 51: 46-56 (2008) Article DOI: 10.1021/jm0706719 BindingDB Entry DOI: 10.7270/Q2445M7Q
					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50057513 ((2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5...) Show SMILES CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O Show InChI InChI=1S/C15H22N2O2/c1-10(2)14-15(19)16-12(9-18)8-11-6-4-5-7-13(11)17(14)3/h4-7,10,12,14,18H,8-9H2,1-3H3,(H,16,19)/t12-,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Displacement of [3H]-PDBu from recombinant Protein kinase C delta				J Med Chem 41: 1476-96 (1998) Article DOI: 10.1021/jm970704s BindingDB Entry DOI: 10.7270/Q2RV0MT8
					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM50057513 ((2S,5S)-5-Hydroxymethyl-2-isopropyl-1-methyl-1,4,5...) Show SMILES CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O Show InChI InChI=1S/C15H22N2O2/c1-10(2)14-15(19)16-12(9-18)8-11-6-4-5-7-13(11)17(14)3/h4-7,10,12,14,18H,8-9H2,1-3H3,(H,16,19)/t12-,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Kyoto University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from PKCgamma C1A domain				J Med Chem 51: 46-56 (2008) Article DOI: 10.1021/jm0706719 BindingDB Entry DOI: 10.7270/Q2445M7Q
					More data for this Ligand-Target Pair