BDBM50058154 7-(4'-Methoxy-2'-spiroindanyl)naltrexone::CHEMBL297933
SMILES: COc1cccc2CC3(Cc12)C[C@@]1(O)C2Cc4ccc(O)c5OC(C3=O)C1(CCN2CC1CC1)c45
InChI Key: InChIKey=CYGKSTHZZXBEKA-ZYRCJVDNSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Delta-type opioid receptor (MOUSE) | BDBM50058154 (7-(4'-Methoxy-2'-spiroindanyl)naltrexone | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description The compound tested for agonistic activity against Opioid receptor delta 1 using [3H]- NT1 as the radioligand. | J Med Chem 40: 1720-5 (1997) Article DOI: 10.1021/jm9700880 BindingDB Entry DOI: 10.7270/Q2FB53M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (MOUSE) | BDBM50058154 (7-(4'-Methoxy-2'-spiroindanyl)naltrexone | CHEMBL2...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description The compound tested for agonistic activity against Opioid receptor mu 1 using [3H]- DAMGO as the radioligand. | J Med Chem 40: 1720-5 (1997) Article DOI: 10.1021/jm9700880 BindingDB Entry DOI: 10.7270/Q2FB53M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Mus musculus (Mouse)) | BDBM50058154 (7-(4'-Methoxy-2'-spiroindanyl)naltrexone | CHEMBL2...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description The compound tested for agonistic activity against Opioid receptor kappa 1 using [3H]U-69,594 as the radioligand. | J Med Chem 40: 1720-5 (1997) Article DOI: 10.1021/jm9700880 BindingDB Entry DOI: 10.7270/Q2FB53M9 | |||||||||||
More data for this Ligand-Target Pair |