Found 5 hits for monomerid = 50059173 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50059173
(CHEMBL3393294)Show InChI InChI=1S/C21H16N2O2/c22-14-18-8-4-5-9-20(18)25-19-12-10-17(11-13-19)21(24)23-15-16-6-2-1-3-7-16/h1-13H,15H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of p38-alpha in human TC28 cells assessed as inhibition of IL-1-induced PGE2 production incubated for 20 mins prior to IL-1 challenge meas... |
J Med Chem 58: 278-93 (2015)
Article DOI: 10.1021/jm501038s
BindingDB Entry DOI: 10.7270/Q269758W |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50059173
(CHEMBL3393294)Show InChI InChI=1S/C21H16N2O2/c22-14-18-8-4-5-9-20(18)25-19-12-10-17(11-13-19)21(24)23-15-16-6-2-1-3-7-16/h1-13H,15H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant 5'-c-myc, His6-tagged p38-alpha using MK2 (46 to 400) as substrate assessed as inhibition of phosphorylation after 60... |
J Med Chem 58: 278-93 (2015)
Article DOI: 10.1021/jm501038s
BindingDB Entry DOI: 10.7270/Q269758W |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50059173
(CHEMBL3393294)Show InChI InChI=1S/C21H16N2O2/c22-14-18-8-4-5-9-20(18)25-19-12-10-17(11-13-19)21(24)23-15-16-6-2-1-3-7-16/h1-13H,15H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of p38-alpha (unknown origin) by p38alpha-MBP IoC assay |
J Med Chem 58: 278-93 (2015)
Article DOI: 10.1021/jm501038s
BindingDB Entry DOI: 10.7270/Q269758W |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50059173
(CHEMBL3393294)Show InChI InChI=1S/C21H16N2O2/c22-14-18-8-4-5-9-20(18)25-19-12-10-17(11-13-19)21(24)23-15-16-6-2-1-3-7-16/h1-13H,15H2,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) |
J Med Chem 58: 278-93 (2015)
Article DOI: 10.1021/jm501038s
BindingDB Entry DOI: 10.7270/Q269758W |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50059173
(CHEMBL3393294)Show InChI InChI=1S/C21H16N2O2/c22-14-18-8-4-5-9-20(18)25-19-12-10-17(11-13-19)21(24)23-15-16-6-2-1-3-7-16/h1-13H,15H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant 5'-c-myc, His6-tagged p38-alpha using MSK1 as substrate assessed as inhibition of phosphorylation after 60 mins by EL... |
J Med Chem 58: 278-93 (2015)
Article DOI: 10.1021/jm501038s
BindingDB Entry DOI: 10.7270/Q269758W |
More data for this
Ligand-Target Pair | |
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