BDBM50059335 (S)-2-({5-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimido[5,4-b][1,4]thiazin-6-yl)-ethyl]-thiophene-2-carbonyl}-amino)-pentanedioic acid::CHEMBL84163
SMILES: Nc1nc2NCC(CCc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Sc2c(=O)[nH]1
InChI Key: InChIKey=HHKAOUMVRGSKLS-AXDSSHIGSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Glycinamide ribonucleotide formyltransferase (GARFTase) (Homo sapiens (Human)) | BDBM50059335 ((S)-2-({5-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Agouron Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human Glycinamide Ribonucleotide Transformylase (GART) using N10-formyl-5,8-dideazafolate (FDDF) as the cofactor . | J Med Chem 40: 2502-24 (1997) Article DOI: 10.1021/jm9607459 BindingDB Entry DOI: 10.7270/Q29C6WJD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Folate receptor alpha (Homo sapiens (Human)) | BDBM50059335 ((S)-2-({5-[2-(2-Amino-4-oxo-4,6,7,8-tetrahydro-3H-...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0.00320 | n/a | n/a | n/a | n/a | n/a |
Agouron Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description compound was tested for the ability to function as transport substrates for the human folate-binding protein(mFBP) | J Med Chem 40: 2502-24 (1997) Article DOI: 10.1021/jm9607459 BindingDB Entry DOI: 10.7270/Q29C6WJD | |||||||||||
More data for this Ligand-Target Pair |