BindingDB PrimarySearch

BDBM50059860 ((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-trienyl)-phosphonic acid::CHEMBL26180::Hydroxy phosphonate, 1

SMILES: [#6]-[#6](-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])-[#6]-[#6](=O)P([#8])([#8])=O

InChI Key: InChIKey=NDLOFZNDXKZSBO-UKTHLTGXSA-N

Data: 3 KI 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50059860
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Farnesyl diphosphate synthase (Homo sapiens (Human))	BDBM50059860 (((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	4.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Assay using farnesyl-ras-CVLS as the protein acceptor substrate.				Biochemistry 31: 3800-7 (1992) Article DOI: 10.1021/bi00130a010 BindingDB Entry DOI: 10.7270/Q2MP51XH
Merck Research Laboratories					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM50059860 (((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory activity against farnesyl pyrophosphate				J Med Chem 40: 2971-90 (1997) Article DOI: 10.1021/jm970226l BindingDB Entry DOI: 10.7270/Q26M37HF
Warner-Lambert Company Curated by ChEMBL					More data for this Ligand-Target Pair
Farnesyl diphosphate synthase (Homo sapiens (Human))	BDBM50059860 (((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description FPTase activity was assayed in the biosynthetically forward direction at 30C.				Biochemistry 31: 3800-7 (1992) Article DOI: 10.1021/bi00130a010 BindingDB Entry DOI: 10.7270/Q2MP51XH
Merck Research Laboratories					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM50059860 (((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of farnesyl protein transferase from bovine brain				Bioorg Med Chem Lett 6: 1291-1296 (1996) Article DOI: 10.1016/0960-894X(96)00238-7 BindingDB Entry DOI: 10.7270/Q2ZC82TQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Squalene synthetase (Rattus norvegicus)	BDBM50059860 (((2E,6E)-1-Hydroxy-3,7,11-trimethyl-dodeca-2,6,10-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of squalene synthase from rat liver microsomes				Bioorg Med Chem Lett 6: 1291-1296 (1996) Article DOI: 10.1016/0960-894X(96)00238-7 BindingDB Entry DOI: 10.7270/Q2ZC82TQ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair