BindingDB logo
myBDB logout

BDBM50060267 1-(1-Aza-bicyclo[2.2.2]oct-3-yl)-3-(3-trifluoromethyl-phenyl)-imidazolidin-2-one::CHEMBL114921

SMILES: FC(F)(F)c1cccc(c1)N1CCN(C2CN3CCC2CC3)C1=O

InChI Key: InChIKey=ICPHVKABHCYQKL-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50060267   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)		BDBM50060267
PNG
(1-(1-Aza-bicyclo[2.2.2]oct-3-yl)-3-(3-trifluoromet...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(C2CN3CCC2CC3)C1=O |THB:13:14:18.17:20.21,(-1.17,-14.36,;.04,-15.05,;-.21,-13.46,;-1.46,-15.63,;1.38,-15.82,;1.38,-17.37,;2.7,-18.14,;4.04,-17.37,;4.04,-15.82,;2.7,-15.05,;5.36,-15.03,;6.76,-15.66,;7.78,-14.52,;7.01,-13.17,;7.62,-11.77,;7.85,-10.36,;9.11,-8.98,;8.66,-7.99,;8.24,-9.07,;8.79,-10.32,;10.61,-10.57,;10.9,-9.2,;5.51,-13.52,;4.36,-12.49,)|
Show InChI InChI=1S/C17H20F3N3O/c18-17(19,20)13-2-1-3-14(10-13)22-8-9-23(16(22)24)15-11-21-6-4-12(15)5-7-21/h1-3,10,12,15H,4-9,11H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
 98n/an/an/an/an/an/an/an/a



Pharmacia& Upjohn

Curated by ChEMBL


Assay Description
In vitro affinity for 5-hydroxytryptamine 3 (5-HT3) receptor by displacement of [3H]BRL-43694 from rat entorhinal cortex

J Med Chem 40: 3369-80 (1997)


Article DOI: 10.1021/jm970060o
BindingDB Entry DOI: 10.7270/Q2X63NNK
More data for this
Ligand-Target Pair